MAP2K3

(redirected from MEK3)

MAP2K3

A gene on chromosome 17q11.2 that encodes a MAPK kinase belonging to a protein kinase signal transduction cascade. MAP2K3 is a dual-specificity kinase, which is activated by cytokines and environmental stress; it catalyses phosphorylation of threonine and tyrosine residues in MAPK14/MAP kinase p38.

Molecular pathology
Defects in MAP2K3 have been described in colorectal cancer.
Mentioned in ?
References in periodicals archive ?
2007) and phosphorylation of p38 MAPK induced the activation of Runx2 via TAK1 and MEK3 signal pathway during early osteoblastic differentiation (Greenblatt et al.
Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes.