MEIS1


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MEIS1

A gene on chromosome 2p14 that encodes Meis homeobox 1, a homeobox protein belonging to the three amino acid loop extension (TALE) family of homeodomain-containing proteins. Meis homeobox 1 is a transcriptional regulator of PAX6 and transcriptional activator of PF4 when complexed with PBX1 or PBX2; it is required for hematopoiesis, megakaryocytopoiesis and vascular development.

Molecular pathology
Meis homeobox 1 may be a cofactor for HOXA7 and HOXA9 in inducing myeloid leukaemias.
References in periodicals archive ?
The researchers did not find any mutations in the BTBD9 gene in study participants, but they found one in the MEIS1 gene that resulted in the production of an aberrant protein.
The family that has the MEIS1 mutation consists of six members-three who had restless legs syndrome had the mutation and the other three without the disease did not.
The presence of the mutation in all affected individuals supports a pathogenic role for the MEIS1 gene, and we now need to confirm this finding with other international research groups who study restless legs syndrome," said Vilarino-Guell.