We didn't aim to address the amount of DEHP and MEHP
release by using Mediset.
To conduct the study, Hixon and graduate student Benjamin Moyer fed either pure corn oil or corn oil laced with three different concentrations of MEHP
(100, 500 and 1,000 milligrams per kilogram of body weight) to pregnant mice in days 17 to 19 of their term.
Pubertal jinekomasti ve kontrol gruplari ile her iki grubu kapsayan tum calisma grubunda plazma DEHP, plazma MEHP
ve pankreatik [alpha]-amilaz ve lipaz duzeyleri arasindaki iliskiye ait Pearson korelasyon katsayilari Tablo 2'de verilmistir.
The researchers didn't find statistical evidence of a relationship between MEHP
and low birth weight or any other deleterious outcome, however.
The percentage of samples (2004-2015) with detectable urinary concentrations of phthalates and parabens biomarkers ranged from 90% to 100% except for MEHP
(78%) and butylparaben (31%) (Table 3).
For the inhibitor experiment, cells were fed basal medium supplemented with 10 [micro]M MEHP
or vehicle, in the presence or absence of 5 [micro]M GW9662.
For all preterm birth, mediation analysis was performed for MEHP
, MECPP, [SIGMA]DEHP, and mono-n-butyl phthalate (MBP) only, because associations in regression models were not statistically significant for other metabolites.
In a cross-sectional study of men recruited from a fertility clinic, urinary concentrations of MEHP
were inversely associated with free [T.
Phthalate metabolites were detected in > 99% of samples except for MEHP
Ten phthalate urinary mono-ester metabolites were measured (MEP (monoethyl phthalate), MnBP (mono-n-butyl phthalate), MiBP (monoisobutyl phthalate), MBzP (monobenzyl phthalate), MCHP (monocyclohexyl phthalate), MEHP
[mono(2-ethylhexyl) phthalate], MEHHP [mono(2-ethyl-5-hydroxyhexyl) phthalate], MECPP [mono(2-ethyl5-carboxypentyl) phthalate], MEOHP [mono(2-ethyl-5-oxohexyl) phthalate], MCPP [mono(3-carboxypropyl) phthalate]), although only MEP, MnBP, and MiBP (metabolites of DEP, DnBP, and DiBP, respectively) were the focus of this study.
To approximate DEHP exposure, we calculated a summary metric (XDEHPm) equal to the molar sum of four DEHP metabolites: MEHP
, mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono(2ethyl-5-oxohexyl) phthalate (MEOHP), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP) using an approach previously described in Zota et al.
study found association with the DEHP metabolites MEHP
[mono(2-ethylhexyl) phthalate], MEHHP [mono(2-ethyl-5-hydroxyhexyl) phthalate] and MEOHP [mono(2-ethyl-5-oxohexyl) phthalate] and AGD (Swan et al.