MEF2C


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MEF2C

A gene on chromosome 5q14 that encodes a member of the MADS-box transcription enhancer factor 2 (MEF2) family of proteins, which are DNA binding and trans-activating and play a role in myogenesis; MEF2C may also be involved in neurogenesis and in the development of cortical architecture.
  
Molecular pathology
MEF2C mutations and deletions are associated with severe mental retardation, stereotypic movements, epilepsy and cerebral malformation.
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Primers for the genes tested [Ahr, Cx40 (connexin 40), Cyplal (cytochrome P450 1A1), Ece1 (endothelin converting enzyme 1), Gata4 (GATA-binding protein 4), Gata6 (GATA-binding protein 6), Hcn4 (hyperpolarization-activated, cyclic nucleotidegated K+ 4), Kdr (kinase insert domain protein receptor), Mef2c (myocyte enhancer factor 2C), Mlc2v (myosin, light polypeptide 2, regulatory, cardiac, slow), Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha), Myh7 (myosin, heavy polypeptide 7, cardiac muscle, beta), Nanog (Nanog homeobox), Nkx2-5 (NK2 homeobox 5), Nppa (natriuretic peptide type A; Anf), Oct4 (POU domain, class 5, transcription factor 1; Pou5f1), Pgp9.
In mice, cooperative control of SMAD and WNT signaling pathways activates multiple transcription factors including Gata4, Nkx2-5, and Mef2c, which control cardiac differentiation (Pal and Khanna 2006).
and colleagues from UT Southwestern show that four gene-regulatory proteins - GATA4, HAND2, MEF2C, and TBX5 (GHMT) - can convert cardiac fibroblasts into beating cardiac-like muscle cells.
Mef2C, the transcription factor which regulates Bop gene in developing heart, is also known to be involved in hypertrophic response in the adult heart (6).
BOP, regulator of the right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart.
University of Texas (Austin, TX) has patented a new polypeptide and the gene encoding therefore, said gene being regulated in cardiac tissue by the transcription factor MEF2C.
Lipton's laboratory, MEF2C turns on specific genes which drive stem cells to become nerve cells.
There's a yin and yang to this MEF2C protein," said Dr.
MEF2C is a transcription factor that turns on specific genes which then drive stem cells to become nerve cells.