ING3

(redirected from MEAF4)

ING3

A gene on chromosome 7q31 that encodes inhibitor of growth (ING) family member 3, a component of the NuA4 histone acetyltransferase (HAT) complex involved in transcriptional activation of genes, principally by acetylating nucleosomal histones H4 and H2A. Acetylation alters nucleosome-DNA interactions and upregulates transcription. The NuA4- HAT complex may be required for activating transcriptional programs linked to oncogene- and proto-oncogene-mediated growth induction, tumour-suppressor-mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a role in DNA repair when recruited to sites of DNA damage.
 
Molecular pathology
Defects of ING1 have been linked to an increased susceptibility to squamous cell carcinoma of the head and neck.
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