MDMA


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Related to MDMA: molly, serotonin

3,4-methylenedioxymethamphetamine

 [meth″ĭ-lēn″di-ok″se-meth″am-fet´ah-mēn]
a compound chemically related to amphetamine and having hallucinogenic properties; it is widely abused. Popularly called Ecstasy.

MDMA

A centrally active phenethylamine derivative related to amphetamine and methamphetamine, with central nervous system excitant and hallucinogenic properties.
Synonym(s): 3, 4-methylenedioxymethamphetamine

MDMA was first synthesized in Germany early in the 20th century and patented for use as an appetite suppressant, but because of its unacceptably high incidence of severe side effects it was never marketed for that indication. During the 1960s and 1970s, it was used experimentally as an adjunct to psychotherapy. Its administration has never been legal in the U.S., except as a Schedule I investigational drug. At present no medical indications for its use are recognized. Since the late 1980s, it has been an increasingly popular drug of abuse among white middle-class adolescents and young adults in metropolitan and suburban communities. More than 2 million tablets are smuggled into the U.S. each week from Belgium, Israel, and the Netherlands. It is also produced in illicit laboratories in this country. Known as "ecstasy" and by a number of other street synonyms (X, E, XTC, M&M, ADAM, Clarity, Lover's Speed, Hug Drug, Bean, Roll), it is usually dispensed as compressed tablets bearing various logos, particularly butterflies, lightning bolts, and four-leaf clovers. Tablets vary in concentration and purity and may contain substances other than MDMA, including caffeine and dextromethorphan, as adulterants or substitutes. MDMA is a club drug, that is, an agent sold and ingested at all-night dance parties ("raves," "techno parties," "trances") where most or all participants use the drug and where decor, entertainment, and ambiance are intended to enhance its psychotropic effects. Pharmacologically MDMA acts as a monoaminergic agonist, promoting copious serotonin release in midbrain centers. Taken orally a dose of 100 mg induces euphoria, loquacity, and a sense of increased energy and heightened social intimacy lasting 4-6 hours. Some users experience perceptual distortion and hallucinations, delirium, anxiety, panic attacks, aggressiveness, paranoia, or seizures. Physiologic effects include elevation of pulse and blood pressure, hyperthermia, dehydration, and muscular twitching and spasms (particularly jaw clenching) sometimes resulting in rhabdomyolysis. Excessive water consumption can lead to water intoxication. After the acute effects wear off, the user may experience depression, flashbacks, or amnesia. Some of these effects can persist or recur for weeks after use is discontinued. MDMA is frequently used in combination with other drugs, especially marijuana. Serially repeated dosing ("piggy-backing") increases the risk of acute psychosis, life-threatening cardiovascular emergencies, and malignant hyperthermia. Use of MDMA accounts for 5000-6000 emergency department visits yearly. Human and animal studies have documented a neurotoxic effect of MDMA on serotonin pathways. A single dose induces significant long-term neurochemical changes and repetitive use has been shown to cause selective and permanent brain damage manifested by irreversible cognitive impairment and memory loss.

MDMA

3,4-methylenedioxymethamphetamine.

MDMA

(ĕm′dē-ĕm-ā′)
n.
A drug, C11H15NO2, that is chemically related to amphetamine and mescaline and was formerly used in psychotherapy but is now illegal. It is used illicitly for its ability to induce euphoria, relaxation, and heightened empathy.

MDMA

abbreviation for 3,4-methylenedioxymethamphetamine.

MDMA

Pharmacologic effects
Hallucinogenic, CNS stimulant, ephedrine-like effects, alertness.
 
Toxicology
Hyperthermia, rhabdomyolysis, DIC, renal failure, cardiac arrhythmias, seizures, hepatotoxicity, hypertension, tachyarrhythmias, hypoglycaemia.
 
Chemistry
The chemical structure resembles mescaline but the base is related to amphetamines.

Route of administration
Oral.

Medical indications
None.

MDMA

3,4 methylenedioxy-methamphetamine. See Ecstasy.
References in periodicals archive ?
It also takes longer to take effect than MDMA, sometimes leading users to take several in succession in the belief that they are not working.
In these regressions age, gender and education level were entered at step 1, followed by DASS depression, anxiety and stress scores at step 2, self-reported doses of alcohol, cannabis, cocaine, opiates and MDMA at step 3, and self-reported doses of LSD and psilocybin at step 4.
MDMA into the Rajiv Gandhi assassination case were " still on" but refused to answer any queries on KP.
The majority of published methods for quantification of MDMA in human plasma focus on MDMA and its minor metabolite, MDA (11-14).
This is consistent with regional trends in which many drug trafficking organizations are moving away from crop-based drugs, such as heroin, into the large-scale production and distribution of synthetic drugs, such as MDMA and crystal meth.
that in the long run, exposure to MDMA may result in increased depressive symptoms" borne of neurotoxic effects.
Handa has confessed to making more than 30 overseas trips in the last three years and bringing back several hundred to several thousand MDMA tablets per visit, police sources said.
What the court said [in the MDMA case] is that the administrator cannot rely exclusively on lack of marketing approval as a condition for no accepted medical use.
CHARGES Seized MDMA and, right, bitcoin MDMA d i ht bit i
Parker, 20, of Manorbier Crescent, Walton, pleaded guilty to four counts of supply of MDMA and one count of offering to supply MDMA, as well as possession with intent to supply MDMA when 390 Ecstasy tablets were found in his possession when he was arrested.
He admitted supplying cocaine and MDMA in its chemical name Methyldioximethylamphethamine between October 1 and March 11, possession of cocaine with intent to supply on March 12, possession with intent to supply MDMA on March 12 and possession the same date of Methymethcathinole MCAT with intent to supply.
The youth claimed that they were supplying MDMA to techies and their friends for house parties in different parts of the city.