CCL2

(redirected from MCP1)
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CCL2

A gene on chromosome 17q11.2-q21.1 that encodes a protein structurally related to the CXC subfamily of cytokines, which are characterised by two cysteines separated by a single amino acid. CCL2 is chemotactic for monocytes and basophils, but not neutrophils or eosinophils; it binds to chemokine receptors CCR2 and CCR4.

Molecular pathology
Altered expression of CCL2 has been linked to diseases characterised by monocytic infiltrates—e.g., psoriasis, rheumatoid arthritis, atherosclerosis.
References in periodicals archive ?
IL6, MCP1 levels in (A-B) F1 and (C-D) F2 adult male offspring.
h] cells MCP1 pro Chemoattractant produced by injured tissue, or infection TNF[alpha] pro Macrophages [CD4.
To evaluate whether gene expression correlates with the corresponding proteins, we analyzed the secretion of IL1[beta], IL6, IL8, and MCP1 in supernatants of cultured precursors and adipocytes (Figure 2C).
Studies made on serum and cerebrospinal fluid (CSF) of 20 ALS patients show an increase of MCP1 and IL-8 levels, indicating a stimulation of proinflammatory cytokine cascade after microglia activation [124].
Gene symbol Gene name change 303649 MCP1 chemokine (C-C motif) ligand 2 2.
Expression of IL6, CCL2/ MCP1, CXCL1/GRO1, and CXCL2/GRO2 is decreased in human fibroblast cells after treatment with 5 [micro]M arsenite for 0-24 hr (Yih et al.