MCP-1


Also found in: Acronyms.

MCP-1

MCP-1

Monocyte chemoattractant protein-1. An older term for a CC cytokine which is critical for development of atherosclerotic lesions, found in endothelial cells, macrophages and in vascular smooth muscle cells of patients undergoing coronary artery bypass procedures. The officially preferred term is now chemokine (C-C motif) ligand 2.
References in periodicals archive ?
We determined the MCP-1 -2518, RANTES -403, CCR5 delta32, and SDF-1 -801 genotypes in DNA isolated from peripheral blood samples of a consecutive unselected series of 83 white women from northern Italy with breast cancer of different stages who underwent surgery, and 141 age-matched healthy white women (control group).
Cross-sectional study design was applied to compare the difference in serum level of cytokines, IL-1[beta], TNF-[alpha] and MCP-1, between schizophrenia patients and HCs.
In this study, we investigated the extent to which adipocytes contribute to overall increases in oxLDL-mediated MCP-1 levels in 3T3-L1 adipocytes.
Increased expression of both MCP-1 and its receptor CCR2 may mediate increased pain signaling through direct excitation of DRG neurons, as well as through attracting macrophages to the DRG," the researchers said.
Therefore, the present study determined the effect of Tan IIA on the expression of MCP-1 and TGF-[[beta].
Further investigation needs to be conducted, with a larger sample size, to evaluate the effect of a powered toothbrush on the inflammatory mediators, MCP-1 and RANTES.
TF production has been reported to be regulated by numerous stimuli, including MCP-1 (20), CRP (16), and hemodynamic forces (21).
Compugen's CGEN-54 is a truncated variant of MCP-1 that is encoded by a novel splice variant, and the results to be presented at the Conference demonstrate the molecule's ability to inhibit the MCP-1/CCR2 pathway both in-vitro and in-vivo.
The team led by Dr Hwyda Arafat, associate professor of Surgery at Jefferson Medical College of Thomas Jefferson University, analyzed the MCP-1 levels in serum samples obtained from patients with confirmed PDA or intraductal papillary mucinous neoplasms (IPMN).
MCP-1 and eotaxin were measured by the Quantikine Human Eotaxin Immunoassay and Quantikine Human MCP-1 Immunoassay (R&D Systems).
The paper, entitled "IL-8 and MCP-1 Secretion is Enhanced by the Peptide-Nucleic Acid Immunomodulator, Product R, in U937 Cells and Primary Human Monocytes", was based on work done by the Company's Immunology Group, and was published in the scientific journal Cytokine (Volume 14, Number 4, pages 234-239).