MCM6


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MCM6

A gene on chromosome 2q14-q21 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA replication related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed by MCM2, MCM4, MCM6 and MCM7 regulates the complex’s helicase activity.
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Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F.
In addition, the -13910T/C variant is located in the MCM6 gene, which encodes a eukaryotic replication factor implicated and required for both initiation and elongation of chromosomal DNA replication.