MCM4

MCM4

A gene on chromosome 8q12-q13 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA replication related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed by MCM2, MCM4, MCM6 and MCM7 regulates the complex’s helicase activity. MCM4 phosphorylation by CDC2 kinase reduces the helicase activity and chromatin binding of the MCM complex.
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A high clinical expression of MCM4 was associated with a poor prognosis," Dr.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.
cerevisiae) MCM4 93041_at mini chromosome maintenance deficient 4 homolog MCM3 160496_s_at mini chromosome maintenance deficient (S.