MCM4

MCM4

A gene on chromosome 8q12-q13 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA replication related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed by MCM2, MCM4, MCM6 and MCM7 regulates the complex’s helicase activity. MCM4 phosphorylation by CDC2 kinase reduces the helicase activity and chromatin binding of the MCM complex.
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Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma.
MCM4 and MCM6 had the highest DOC and DON concentrations (Table 1), which may explain why both estimated and observed richness in those samples were not lower than in other samples, taking confidence bounds into account (Fig.
7A), samples (MCMI, MCM2, MCM7, MCM8) collected from the same depth from Lake Fryxell (median oxygen, low salinity) clustered together regardless of season, followed by samples (MCM3 and MCM5; MCM4 and MCM6) from Lake WLB from different oxygen levels and salinities.
A high clinical expression of MCM4 was associated with a poor prognosis," Dr.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.
cerevisiae) MCM4 93041_at mini chromosome maintenance deficient 4 homolog MCM3 160496_s_at mini chromosome maintenance deficient (S.