MCM3

MCM3

A gene on chromosome 6p12 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA-replication-related proteins. The complex is required for the entry in S phase and for cell division. MCM3 interacts directly with MCM5/CDC46; it is acetylated by MCM3AP, a chromatin-associated acetyltransferase, which inhibits the initiation of DNA replication and cell cycle progression.
References in periodicals archive ?
MCM3AP is an acetyltransferase that acetylases MCM3, and plays a role in DNA replication (Takei et al.
MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3.
They found two, MCM3 and MCM7, that limited HIF-1a's activity, and were also part of the DNA replication machinery.
We confirmed ER[alpha]-dependent responses to BPA, BPAF, and Zea by detecting endogenous gene expression of PR, GREBI (gene regulation by estrogen in breast cancer 1), MCM3 (minichromosome maintenance complex component 3), and SPUVE (also known as PRSS23; a member of the trypsin family of serine proteases) by real time-PCR (Figure 4).
GREB, MCM3, and SPINE have been reported to be ER-responsive genes (Henley et al.
As shown in Figure 3A, the expression of pS2, MYC, GREB1, SPUVE, and MCM3 was potentiated by [E.
However, some genes measured in this study, including GREB1 and MCM3, were not altered by treatment with MAA alone (Figure 3A).
As a result of this agreement, WaveCall intends to make the industry leading WaveCall 3000 and WaveCall MCM3 fixed maritime units available in all areas served by the Globalstar satellite network.
The WaveCall MCM3 uses 3 simultaneously connected channels to provide voice and data speeds of up to 144 kbps using data compression.
Strain MCM3 grew only on mineral oil in addition to crude oil.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.