MCM2


Also found in: Acronyms.

MCM2

A gene on chromosome 3q21 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA-replication-related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed by MCM2, MCM4, MCM6 and MCM7 regulates the complex’s helicase activity. MCM2 is phosphorylated, and thus is regulated, by protein kinases CDC2 and CDC7. It is also the retired HUGO symbol for MCM7.
References in periodicals archive ?
MCM1, MCM2, MCM3, and MCM4 (Table 3), leading us to conclude that these species may tolerate a range of salinities (Layboum-Parry and Pearce, 2007).
7A), samples (MCMI, MCM2, MCM7, MCM8) collected from the same depth from Lake Fryxell (median oxygen, low salinity) clustered together regardless of season, followed by samples (MCM3 and MCM5; MCM4 and MCM6) from Lake WLB from different oxygen levels and salinities.
In one set of experiments dense cultures of MCM2 were produced by inoculating crude oil/mineral salts broth with spores.
22) That antibody cocktail targeted MCM2 and TOP2A, markers that are highly expressed in hyperactive basal/parabasal cells, as well as in cancer cells during the aberrant induction of S phase.
cerevisiae) PCNA 101065_at proliferating cell nuclear antigen MCM2 93112_at mini chromosome maintenance deficient 2 CDC6 103821_at cell division cycle 6 homolog (S.
They noted that novel markers of proliferation such as MCM2 and AgNOR may be useful adjuncts in this situation but they present technical difficulties and are not widely used.