MCM2


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MCM2

A gene on chromosome 3q21 that encodes one of the highly conserved mini-chromosome maintenance (MCM) proteins that are involved in initiating eukaryotic genome replication. The hexameric protein complex formed by MCM2-7 is a key component of the pre-replication complex, and may be involved in forming replication forks and in recruiting other DNA-replication-related proteins; it is required for the entry in S phase and for cell division. The sub-complex formed by MCM2, MCM4, MCM6 and MCM7 regulates the complex’s helicase activity. MCM2 is phosphorylated, and thus is regulated, by protein kinases CDC2 and CDC7. It is also the retired HUGO symbol for MCM7.
References in periodicals archive ?
Strains MCM1 and MCM2 also grew on mineral oil, toluene and xylene.
Current and Emerging Prognostic Parameters in Clear Cell Renal Cell Carcinoma (ccRCC) Current Prognostic Parameters in ccRCC Patient factors Age Sex Pathologic factors pTNM Histologic type Fuhrman grade LVI Tumor necrosis Clinical factors ECOG performance status Hgb level Serum lactate dehydrogenase Emerging Potential Molecular Prognostic and Predictive Parameters in ccRCC Hypoxia inducible HIF1 CAIX CAXII CXCR4 VEGF/VEGFR-R ILGF1 Cell adhesion markers EpCAM E-cadherin [alpha]-Catenin Catenin-6 Proliferation markers Ki-67 MCM2 Cell cycle regulators Cyclin p27 Apoptosis regulators p53 Bcl2 Smac/DIABLO mTOR pathway PTEN Akt Phos S6k an Abbreviations: ECOG, Eastern Cooperative Oncology Group; Hgb, hemoglobin; LVI, lamina propria invasion.
We found that genes required for the replication of chromosomal DNA (PCNA, FEN1, CDC6, MCM2, MCM3, MCM4, MCM5, ORC1, ORC6, RRM1, RRM2) and genes required for postreplicative phases of the cell division cycle (e.