MCHR1

MCHR1

A gene on chromosome 22q13.2 that encodes a G protein-coupled receptor and integral plasma membrane protein which binds melanin-concentrating hormone. MCHR1 can inhibit cAMP accumulation and stimulate intracellular calcium accumulation, and is probably involved in the neuronal regulation of food consumption.
References in periodicals archive ?
Global Markets Direct's, 'Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1) - Pipeline Review, H1 2016', provides in depth analysis on Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1) targeted pipeline therapeutics.
The report provides comprehensive information on the Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
The report provides a snapshot of the global therapeutic landscape for Melanin-Concentrating Hormone Receptor 1 (G-Protein Coupled Receptor 24 or MCH-1R or Somatostatin Receptor-Like Protein or MCHR1 or GPR24 or SLC1)
Examples of these upregulated genes include LALBA [6] (lactalbumin, alpha-), which encodes a principal milk protein that enables lactose production; CCKAR (cholecystokinin A receptor), which encodes a major physiological mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach; HCRTR2 [hypocretin (orexin) receptor 2], which encodes a protein involved in stimulation of food intake; MCHR1 (melanin-concentrating hormone receptor 1), which encodes a protein involved in neuronal regulation of food consumption; and DMP1 (dentin matrix acidic phosphoprotein 1), which encodes an extracellular matrix protein crucial for proper mineralization of bone and dentin (see Table 2 in the online Data Supplement).
6] Human genes: LALBA, lactalbumin, alpha-; CCKAR, cholecystokinin A receptor; HCRTR2, hypocretin (orexin) receptor 2; MCHR1, melanin-concentrating hormone receptor 1; DMP1, dentin matrix acidic phosphoprotein 1; AES, amino terminal enhancer of split; CEACAM1, carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); SFTPB, surfactant protein B; FREM2, FRAS1 related extracellular matrix protein 2.
Our goal here was to screen our in-house synthesized compounds to discover potent and selective inhibitors of human MCHR1 and MCHR2 receptors.