MCAD


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MCAD

MCAD

abbreviation for medium-chain acyl-CoA dehydrogenase, an enzyme involved in degradation of medium-chain length fatty acids. Deficiency of the enzyme (MCAD deficiency) is characterized by recurring episodes of hypoglycemia, vomiting, and lethargy, with urinary excretion of medium-chain dicarboxylic acids, minimal ketogenesis, and low plasma and tissue levels of carnitine.

ACADM

A gene on chromosome 1p31, which encodes a medium-chain-specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase, which catalyses the initial step of the mitochondrial fatty acid beta-oxidation pathway.

Molecular pathology
ACADM defects cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterised by hepatic dysfunction, fasting hypoglycemia and encephalopathy, which causes death in infancy.
References in periodicals archive ?
Upon completion of the acquisition, MCAD will be part of Symetri and the Design Management business area.
The Global MCAD Software market can be segmented into two product segments: Multidiscipline and Design Focused.
The city appealed the case to Worcester Superior Court, which sent it back to the MCAD in 2013.
Desktop EDA plug-in for the target MCAD design tool, teams save time by having a both full synchronization features as well as PCB copper design elements.
Children born with MCAD deficiency cannot digest medium-chain fats such as coconut oil.
com/beccathompson DEFICIENCY MCAD deficiency is the lack of an enzyme that makes it impossible to digest certain kinds of fat.
La Tabla 1 muestra los valores promedio (5 determinaciones por cada muestra), para la oxidacion de palmitato y miristato tritiados en nmol/hora/mg proteina y el porcentaje de oxidacion de los sustratos tritiados por parte de los fibroblatos de los pacientes con deficiencia de MCAD comparados con los controles paralelos.
A review of charts in children with Reye's would likely show that 10%-13% were, in fact, MCAD deficiency.
The results for those who only use MCAD software were 52 percent and 74 percent, respectively.
We had never heard of MCAD but in simple terms it means people with the disorder cannot tolerate not having food stores in them.
The spectrometers, supplied by Block, are the most expensive part of the MCAD system, which at its present manufacturing volume costs several an hundred thousand dollars.
MCAD complainants often lay claim to extreme psychic distress even in cases where you'd think a certain amount of roll-with-the-punches mental stoicism would be a prerequisite for the jobs they were after.