Also found in: Acronyms, Wikipedia.
Abbreviation for medium-chain acyl-CoA dehydrogenase.
abbreviation for medium-chain acyl-CoA dehydrogenase, an enzyme involved in degradation of medium-chain length fatty acids. Deficiency of the enzyme (MCAD deficiency) is characterized by recurring episodes of hypoglycemia, vomiting, and lethargy, with urinary excretion of medium-chain dicarboxylic acids, minimal ketogenesis, and low plasma and tissue levels of carnitine.
ACADMA gene on chromosome 1p31, which encodes a medium-chain-specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase, which catalyses the initial step of the mitochondrial fatty acid beta-oxidation pathway.
ACADM defects cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterised by hepatic dysfunction, fasting hypoglycemia and encephalopathy, which causes death in infancy.