MCAD


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MCAD

MCAD

abbreviation for medium-chain acyl-CoA dehydrogenase, an enzyme involved in degradation of medium-chain length fatty acids. Deficiency of the enzyme (MCAD deficiency) is characterized by recurring episodes of hypoglycemia, vomiting, and lethargy, with urinary excretion of medium-chain dicarboxylic acids, minimal ketogenesis, and low plasma and tissue levels of carnitine.

ACADM

A gene on chromosome 1p31, which encodes a medium-chain-specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase, which catalyses the initial step of the mitochondrial fatty acid beta-oxidation pathway.

Molecular pathology
ACADM defects cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterised by hepatic dysfunction, fasting hypoglycemia and encephalopathy, which causes death in infancy.
References in periodicals archive ?
Collaboration between ECAD and MCAD has existed as long a product design has; it originated as paper being passed back and forth.
The results for those who only use MCAD software were 52 percent and 74 percent, respectively.
We had never heard of MCAD but in simple terms it means people with the disorder cannot tolerate not having food stores in them.
besides reporting the frequency of the prevalent MCAD allele in the screened population, conclude that OLA is applicable to population screening; thus, any specific mutation in any gene could be tested by this technique.
It is telling because the case history on which the MCAD based its decision tells the story of how the office of the city manager and the Human Resources Department for years paid lip service to the notion that it was proper to take measures to ensure equal opportunity in hiring and promotions, but were less than conscientious in putting those measures in practice.
The signs and symptoms of MCAD deficiency usually appear during infancy or early childhood and can include vomiting, lack of energy and low blood sugar.
To harness this potential and prepare your design system for the ongoing convergence in the MCAD and ECAD worlds, the minimum requirement is for an electronics design system that allows 3D models to be imported and attached to components.
The MCAD market, still the biggest segment of the euro 10 billion global PLM market, is a particularly dynamic market in Europe.
The high prevalence of a single mutation responsible for the MCAD deficiency has led to the possibility of developing diagnostic methods based on molecular analysis [5-7,91.
Further, the report also discusses that the increasing demand for open-source software affects the growth of the commercial vendors in the Global MCAD market.
Last year in this space, and in his complaint to the MCAD, Mr.