MC4R

(redirected from MC4-R)

MC4R

A gene on chromosome 18q22 that encodes a receptor for alpha, beta and gamma melanocyte stimulating hormone (MSH), the activity of which is mediated by G protein-activated adenylate cyclase and expressed in the brain, placenta and gut.

Molecular pathology
Defects in MC4R are linked to obesity.
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References in periodicals archive ?
Particularly, MC4-R has recently been identified as an important regulating mechanism for appetite, body weight and insulin secretion which represents a novel target for the treatment of obesity and diabetes.
It's a reasonable hypothesis that proteins like the MC4-R direct weight regulation based on instructions from leptin, but they could just as well be involved in some other pathway," Barsh said.
Drug companies could look for small molecules that either block the production or action of AGRP or stimulate the MC4-R (or its relative the MC3-R, which may also be involved in the response).