MAVERIC


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MAVERIC

Midlands trial of empirical Amiodarone Versus Electro-physiologically guided Intervention and Cardioverter implant. A trial that asked whether patients who might benefit from an implantable cardioverter-defibrillator (ICD) could be identified prospectively by electrophysiology (EP) studies—and if so, would implanted ICDs prevent sudden cardiac death (SCD)—comparing EP-guided interventions (anti-arrhythmic drugs, coronary revascularisation and ICD) to empirical amiodarone therapy.

Conclusion
No. Prospective selection of patients to receive the ICD by EP study did not improve survival compared to empirical amiodarone therapy among survivors of ventricular tachycardia, ventricular fibrillation or SCD; ICD implantation improved survival regardless of treatment. Routine EP studies have no role in managing such patients, who should be offered empirical ICD therapy according to the results of other secondary prevention ICD trials.
References in periodicals archive ?
Recombinant collaborated with the MAVERIC team to create a system to streamline and integrate key elements of large scale recruitment and enrollment of patients for GenISIS and MVP-communicating with veterans via mail and telephone call centers regarding MVP participation; scheduling research-related appointments in coordination with schedules maintained in VistA (Veterans Health Information Systems and Technology Architecture), the VA's electronic medical record system; collecting and managing patients' research consent and initial clinical trial questionnaire data; and tracking tissue samples collected as part of the research enrollment process.
Recombinant and MAVERIC are continuing to work together on the next phases of GenISIS, which will include the clinical data warehouse integrating genomic data with the clinical data maintained in the VistA EMR, biorepository management, cohort discovery and hypothesis testing tools, and the genomics analysis framework.
MAVERIC selected DataLabsXC because of the product's many benefits, including ease of integration, ease of use, ease of adoption, and the ability to maintain and support the software with minimal time and monetary investment.