MARS

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MARS

Monitored Atherosclerosis Regression Study. A trial assessing the effects of lovastatin on coronary angiographic findings in patients with coronary artery disease with several substudies
Conclusion Lovastatin lowered total cholesterol level by 32%, LDL cholesterol by 38% and apolipoprotein B by 26%, and raised HDL cholesterol by 8.5%. Non-significant improvement in coronary artery stenosis occurred in lovastatin patients. Lovastatin significantly lowered apoB, apoC-III, apoE, and slightly increased apoA-I. The reducing effect of lovastatin on apoB-containing lipoproteins was mediated by a selective decrease in cholesterol-rich lipoprotein B particles

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