MAP2K3

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MAP2K3

A gene on chromosome 17q11.2 that encodes a MAPK kinase belonging to a protein kinase signal transduction cascade. MAP2K3 is a dual-specificity kinase, which is activated by cytokines and environmental stress; it catalyses phosphorylation of threonine and tyrosine residues in MAPK14/MAP kinase p38.

Molecular pathology
Defects in MAP2K3 have been described in colorectal cancer.
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Several years later, another group of scientists has interestingly revealed that, without drug treatment, the [gamma]-globin mRNA level is increased sufficiently solely by overexpressing MAPKK3 and MAPKK 6 which are the direct upstream activators of p38 in K562 cells [81].
Higher doses of arsenic increase levels of jun kinases (JNKs), possibly via mitogen-activated protein kinase kinases, such as MAPKK3, and also activate MAP kinases such as extracellular signal regulated kinase (ERK3) (Cavigelli et al.