MAPK14


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Related to MAPK14: MAPK13, MAPK8

MAPK14

A gene on chromosome 6p21.3-p21.2 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK14 is phosphorylated and activated by MAP kinases or autophosphorylated by interaction with MAP3K7IP1/TAB1 protein.

MAPK14 substrates
Transcription regulator ATF2, cell cycle regulator CDC25B and tumour suppressor p53, suggesting that MAPK14 has a role in stress-related transcription and cell cycle regulation, as well as in
genotoxic stress response.
References in periodicals archive ?
B binding protein Transforming growth factor, beta 2 TCFBR2 Transforming growth factor, beta receptor II TCF/Smad pathway SMAD1 SMAD family member 1 SMAD6 SMAD family member 6 S0X4 SRY (sex determining region Y)-box 4 SP1 Spl transcription factor CTNNB1 CREB binding protein Ras/MAPK(non-Smad) RHOA Ras homolog gene family, pathway member A RH08 Ras homolog gene family, member B MAP3K7 Mitogen-activated protein kinase kinase kinase 7 MAPK14 Mitogen-activated protein kinase 14 Downstream effector BCL2L1 BCL2-like 1 CDC6 Cell division cycle 6 homolog CDKN1B Cyclin-dependent kinase inhibitor 1B CEBPB CCAAT/enhancer binding protein (C/EBP), beta FN1 Fibronectin 1 CADD45B Growth arrest and DNA-damage-inducible.