MAPK13


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MAPK13

A gene on chromosome 6p21.31 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK13 is phosphorylated and activated by MAP kinases—especially MKK3 and MKK6; it is closely related to p38 MAP kinase and both are activated by pro-inflammatory cytokines and environmental stress, and in turn phosphorylate downstream targets.
References in periodicals archive ?
For MAPK13, that pocket itself has some obstructions that make it more crowded and harder to access, so these older drugs can't fit into the pocket to block activity.
We sculpted the drugs so they're better able to bind in the MAPK13 pocket," Dr.
Holtzman also sees a possible role for MAPK13 inhibitors in related conditions with excess mucus production, such as cystic fibrosis and even the common cold.