MAPK pathway

MAPK pathway

Mitogen-activated protein kinase pathway. An evolutionarily conserved cascade in which three families of protein kinases act in sequence to effect cell responses to various stimuli. An activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. ERK MAPKs are activated by mitogenic stimulation; CSBP2 and JNK MAPKs are activated by environmental stress (e.g., osmotic shock, UV irradiation), wound stress and inflammatory factors.
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Using mathematical modeling and experiments in which he tweaked the molecular wiring of the mitogen activated protein kinase (MAPK) pathway that mediates the cells' salt-sensing system, he revealed a sensory misperception: Because of the way the MAPK pathway is set up, the cells interpret an eight-minute oscillation as an ever-increasing staircase of salt concentration.
Using mathematical modeling and experiments in which he tweaked the molecular wiring of the mitogen activated protein kinase (MAPK) pathway that mediates the cells salt-sensing system, he revealed a sensory misperception: Because of the way the MAPK pathway is set up, the cells interpret an eight-minute oscillation as an ever-increasing staircase of salt concentration.
The p38 MAPK pathway has been implicated in the induction of apoptosis by varying extracellular stimuli (Dolado et al.
The MAPK pathway represents a prime target for therapeutic intervention in cancer.
Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through mapk pathway activation and reactive oxygen species induction.
Moreover, our recent studies demonstrated that PHC could attenuate NO production and iNOS expression by suppressing the activation of the p38 MAPK pathway, and that b-arrestin-1 is closely related to p38 MAPK signaling pathway (16,17).
PI3K pathway activity was monitored by RT-qPCR array while MAPK pathway activity was followed by protein profiling array.
Experiments showed that Shc blocks Erk function by sequestering it away from the Ras-Raf-Mek MAPK pathway in the worms.
The p38 MAPK pathway was originally described as a mammalian homolog to a yeast osmolarity sensing pathway.
In the MAPK pathway, extracellular signals such as growth factors, mitogens, cytokines, and various forms of environmental stresses activate the phosphorylation of one or several of the three members: extracellular signal-regulated kinases (ERKs), also referred as p44/42 MAP kinase; p38 MAP kinases; and c-Jun N-terminal kinases (JNKs, also termed as stress-activated protein kinases) (14,15).
These data suggest that the inhibitory effect of ODN on FSH-induced meiotic resumption might be via the MAPK pathway.
The target is thought to be a key part of the expansive MAPK pathway.