mitogen-activated protein kinase

(redirected from MAPK cascade)

MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.

mitogen-activated protein kinase



A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
References in periodicals archive ?
2004) investigated the involvement of a mitogen-activated protein MAPK cascade in this process.
Interestingly, regulation of different signalling pathways can be brought about by one specific MAPK cascade.
Because edr1-mediated resistance was salicylate- and NPR1/NIM1-dependent and did not lead to enhanced levels of salicylate and constitutive PR gene expression, EDR1 is unlikely to control the AtMPK4 MAPK cascade.
This study suggested that LHR expression in cumulus cells is involved in FSH-induced oocyte meiotic resumption, which process is possibly regulated by MAPK cascade.
Differences in activity between matuzumab and cetuximab in A431 cells may rely on MAPK cascade inhibition.
Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential.
In addition to eotaxin regulation, the MAPK cascade participates in airway remodeling by inducing many other chemokines.
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor.
Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons.
MAPK cascades have been shown to participate in a diverse array of cellular functions such as cell growth, differentiation, and apoptosis (10,21).
Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2.