MAP3K9

MAP3K9

An oncogene on chromosome 14q24.3-q31 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K9 acts as an upstream activator of the JNK signal transduction cascade by phosphorylating MAP2K4/MKK4 and MAP2K7/MKK7; the JNK signalling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. MAP3K9 also plays a role in mitochondrial death signalling pathway, including cytochrome c release, which triggers apoptosis.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.

Molecular pathology
MAP3K9 may play a role in oesophageal cancer susceptibility and/or pathogenesis.
References in periodicals archive ?
In addition, 24% of melanomas were found to exhibit MAP3K5 (MAP kinase kinase kinase 5; synonyms: ASK1, MEKK5) and MAP3K9 (MAP kinase kinase kinase 9; synonyms: MlK1, MEKK9) mutations.
2011) Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.
25) Deletion of chromosome 14 extending from the q24 to q31 band encompasses additional candidate genes involved in tumorigenesis, including SEL1L (the human ortholog of the C elegans sel-1 suppressor enhancer of lin-12), CHES1 (checkpoint suppressor 1), and MAP3K9 (mitogen activated protein kinase kinase kinase 9) genes.