MAP3K7

MAP3K7

A gene on chromosome 6q15 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K7 plays a key role in the cascades of cellular responses triggered by environmental changes, as well as ceramides. It mediates signal transduction of TRAF6; various cytokines, including IL1; transforming growth factor-beta (TGFB), and TGFB-related factors like BMP2 and BMP4; toll-like receptors (TLR); tumour necrosis factor receptor CD40; and B-cell receptor (BCR). Once activated, MAP3K7 acts as an upstream activator of the JNK and the P38 signal transduction cascades by phosphorylating and activating several MAP kinase kinases.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
Mentioned in ?
References in periodicals archive ?
Promising targets, including MAP3K7 and P70-S6 Kinase 1 have been extensively reviewed using peer-reviewed literature and preclinical data.
MAP3K7 is linked to IL1 receptor and tumor necrosis factor (TNF) receptor signalings (Sato et al.
Dominant-negative MAP3K7 induces GO exit in the quiescent liver and accelerates hepatic cell cycle progression during regeneration (Bradham et al.
B binding protein Transforming growth factor, beta 2 TCFBR2 Transforming growth factor, beta receptor II TCF/Smad pathway SMAD1 SMAD family member 1 SMAD6 SMAD family member 6 S0X4 SRY (sex determining region Y)-box 4 SP1 Spl transcription factor CTNNB1 CREB binding protein Ras/MAPK(non-Smad) RHOA Ras homolog gene family, pathway member A RH08 Ras homolog gene family, member B MAP3K7 Mitogen-activated protein kinase kinase kinase 7 MAPK14 Mitogen-activated protein kinase 14 Downstream effector BCL2L1 BCL2-like 1 CDC6 Cell division cycle 6 homolog CDKN1B Cyclin-dependent kinase inhibitor 1B CEBPB CCAAT/enhancer binding protein (C/EBP), beta FN1 Fibronectin 1 CADD45B Growth arrest and DNA-damage-inducible.