MAP3K2

MAP3K2

A gene on chromosome 2q14.3 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K2 regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7, and it plays a role in caveolae kiss-and-run dynamics. MAP3K2 also interacts with MAPK8, SH2D2A, STK38, and XIAP.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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Forward (F) and reverse (R) primers for MAP3K3 (XM_015299375, F: 5'-TGA CCC GGA AAT ACA CTC GC; R: 5'-ACA TTC CCA GCA GAG TCA CG), MAP3K2 (XM_015290042, F: 5'-TGA GGG ACC CAC CAG AAA GA; R: 5'-GCG AGT CAC GTT CTC TGT CA), AQP4 (NM_001004765, F: 5'-GTG CCA GTA TGA ACC CTG CT; R: 5'-AAG AGC ACC AGC AAG GAC TG), and IGF2BP3 (NM_001006359, F: 5'-GCC TTG GCA GTT GGA GCT AT; R: 5'-AGC TTG GCA TCT GGT CCT TC) were designed using the Primer3 program (National Center for Biotechnology Information [NCBI] database) and synthesized by Genotech Co.
The miRNA gga-miR-20b-5p targets 581 genes, with the top-ranking/ top-scoring gene being MAP3K2 (target rank 1, score 100).
The expression of gga-miR-20b-5p was significantly decreased, and the expression of its target gene MAP3K2 significantly increased, in the IML of NE-induced M5.
In humans and/or mice, MAP3K family members MAP3K3 and MAP3K2 were reported as the regulators of the NF-[kappa]B and MAPK pathways, and play an important role in enhancing the immune response in the microenvironment of the infected cells [24,25].