MANBA

MANBA

A gene on chromosome 4q22-q25 that encodes a member of the glycosyl hydrolase 2 family, which localises to the lysosome where it is the final exoglycosidase in the N-linked glycoprotein oligosaccharide catabolism pathway.
 
Molecular pathology
Defects in MANBA cause beta-mannosidosis.
References in periodicals archive ?
050): the 'Na+/Cl- dependent neurotransmitter transporters' pathway (#15) (specified above), and the 'other glycan degradation' pathway (#20) (AGA, HEXA, HEXB, ENGASE, FUCA2, FUCA1, MANBA, GLB1, MAN2C1, MAN2B2, NEU1, NEU3, MAN2B1, NEU2, GBA, and NEU4).