atrogin-1

(redirected from MAFbx)

atrogin-1

An E3 ubiquitin ligase expressed in cardiac and skeletal muscle that directs muscle protein degradation after the muscle atrophy response has been triggered by Akt1-induced phosphorylation of FOXO, a transcription factor which also activates ubiquitin ligases and MuRF-1. Atrogin-deficient mice are resistant to muscle atrophy.
References in periodicals archive ?
As vias de sintese como a da mTOR ou de degradacao como MURF-1 e MAFbx estao constantemente sendo estudadas sobre a influencia de diversas condicoes para a potencializacao ou controle de sua expressao e nesse sentido tem sido considerada para estudos cientificos.
Curcumin prevents lipopolysaccharide-induced atrogin-1/ MAFbx upregulation and muscle mass loss.
reported that TNF-[alpha] upregulates the expression of MuRF1 but not of MAFbx (Cai et al.
cDNA synthesis using 10 ng of total RNA and subsequent PCR amplification was performed using a one-step qRT-PCR kit (Superscript III, Invitrogen) and gene specific Taqman[R] primers and probes (Applied Biosystems, Foster City, CA) designed against MAFbx (Mm00499518_m1) and GAPDH (Mm99999915_g1).
Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle.
Repeated resistance exercise training induces different changes in mRNA expression of MAFbx and MuRF-1 in human skeletal muscle.
Interestingly, gastric cancer patients with no weight loss exhibited an increase in calpain activity in the rectus abdominis muscle, without any change in the expression of key components of the UPS, MuRF-1, and MAFbx [45].
The nuclear accumulation of NF-[kappa]B promotes the transcriptional upregulation of muscle-specific E3 ubiquitin-ligases, MuRF-1 and MAFbx, which in turn tag myofibrillar proteins (i.