MAD2L1

MAD2L1

A gene on chromosome 4q27 that encodes a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate, and which may recruit MAD2L1 to unattached kinetochores. MAD2L1 is required for the execution of the mitotic checkpoint, which monitors kinetochore-spindle attachment and inhibits the anaphase-promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
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Other upregulated genes were related to cell proliferation and its control, such as cyclin-dependent kinase gene CDK1/CDC2; cyclin genes CCNA2, CCNB1, CCNB2, and CCNL2; the DLG7 component of the mitotic apparatus; the gene encoding the checkpoint kinase involved in response to DNA damage, CHEK1/CHK1; and BUB1 and MAD2L1, components of the spindle checkpoint.
22) Genes that were more highly expressed in metastatic carcinomas included those involved in DNA synthesis and repair, mitosis, and cell cycle regulation, such as RFC5, TOP2A, RFC4, and MAD2L1, which have previously been shown to be highly expressed in proliferating cells.