MAC regimen

MAC regimen

Gynecologic oncology A regimen for managing choriocarcinoma Agents MTX, dactinomycin, chlorambucil; MR 'failures' may respond to other chemotherapy–eg, bleomycin, cisplatin, hydroxyurea, vinblastine
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In addition to the impressive response rates reported in this group of heavily pretreated patients, who had received an average of approximately four prior regimens (range of one to eight) prior treatments, the MAC regimen resulted in a marked improvement in the serum creatinine levels in patients with renal insufficiency," stated Berenson.
One of the most important outcomes of this experience was the ability of the MAC regimen to improve kidney function in patients with severe myeloma kidney damage, preventing the need for those patients with kidney dysfunction to go on dialysis.