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M-tropic strain

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M-tropic strain
AIDS A strain of HIV-1 that infects macrophages and activated T cells, the entry of which is facilitated by CCR5, a coreceptor for chemokines, RANTES, MIP 1α, MIP 1β; binding of these chemokines to CCR5 blocks the entry of M strains. Cf T-tropin strain.


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The use of CCR5 by M-tropic strains, CXCR4 by T-tropic strains, and both receptors by dual-tropic strains had suggested a simple paradigm for the cellular determinants of tropism whereby CCR5 would be expressed on macrophages, CXCR4 on T cells, and both types of co-receptors on primary lymphocytes.
 
 
 
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