amsacrine

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amsacrine

/am·sa·crine/ (am´sah-krēn) an antineoplastic that inhibits DNA synthesis; used to treat some forms of leukemia.

amsacrine

A topoisomerase inhibitor with antineoplastic activity; it can also intercalate into the DNA of tumour cells, altering major and minor grooves therein, thereby inhibiting DNA replication and transcription by reducing association between the altered DNA and DNA polymerase, RNA polymerase and transcription factors.

Indications
Acute lymphoblastic leukaemia, lymphoma.

Adverse effects
Bone marrow suppression.

amsacrine

A cytotoxic drug used to treat acute myeloid leukaemia. A brand name is Amsidine.