Lynch syndrome

Lynch syndrome

(linch),
type I, familial colorectal cancer, generally occurring at an early age; type II, familial colorectal cancer occurring at an early age in conjunction with female genital cancer or cancers at other sites proximal to the bowel.

Lynch syn·drome

(linch sin'drōm)
Type I, familial colorectal cancer, generally occurring at an early age; type II, familial colorectal cancer occurring at an early age in conjunction with female genital cancer or cancers at other sites proximal to the bowel.

Lynch syndrome

(lĭnch)
An autosomal dominant predisposition to colon cancer and other solid tumors. People with Lynch I syndrome are susceptible to colon cancer alone, whereas those with Lynch II syndrome have an additional tendency to get cancers of the colon, ovaries, breasts, and/or uterus. It is also known as hereditary nonpolyposis colorectal cancer.

Lynch syndrome

Hereditary non-polyposis colorectal cancer, a strong familial tendency to this class of cancers resulting from germ-line mutations in the DNA mismatch-repair genes MLH1, MSH2, MSH6 and PMS2. Three to four percent of all colorectal cancers involve the Lynch syndrome. Affected people are liable to develop cancers at an earlier age than average—around age 45—and most show evidence of MICROSATELLITE INSTABILITY.
References in periodicals archive ?
The ROCA Test is intended for post-menopausal women aged between 50 and 85, with no known ovarian cancer risk factors, or for women between 35 and 85, who are considered to be at high risk of ovarian cancer due to a family history of ovarian or breast cancer, or a mutation in specific genes such as the BRCA1 or BRCA2 or Lynch Syndrome genes.
Both father and son had Lynch syndrome - a genetic condition that raises the risk of bowel cancer.
Both father and son had Lynch syndrome - a genetic condition that significantly increases the chances of bowel and colon cancer.
She announced in May she was stepping down from her cabinet post with immediate effect because of a battle with Lynch Syndrome, which increases the chance of developing cancer.
After being diagnosed with Lynch syndrome in June 2011, Janet was told she would have to have an elective hysterectomy.
The research by Newcastle University and the University of Leeds found that being overweight more than doubled the risk of bowel cancer in people with Lynch Syndrome.
The research by Newcastle University and the University of Leeds found that being over weight more than doubled the risk of bowel cancer in people with Lynch Syndrome.
Individuals with Lynch syndrome have increased risk of colon (52%-82%), endometrial (25%-60%), and ovarian (4%-24%) cancers.
A molecular technique for identifying Lynch Syndrome, a type of colon cancer, is important due to the possibility of nuclear microsatellite instability associated with an increased chance of other carcinomas.
Bowel Cancer UK says only half of hospitals in England and Wales test bowel cancer patients under 50 for Lynch syndrome.
Until about six years ago, Matthew was having colonoscopies every couple of years and fully expecting to get bowel cancer too, due to a rare hereditary condition called Lynch Syndrome.
coli) (MLH1), (4) DNA mismatch repair protein Msh2 (MSH2), mutS homolog 6 (MSH6), mismatch repair endonuclease PMS2 (PMS2), and epithelial cell adhesion molecule (EPCAM), such as occurs in patients with Lynch syndrome, for whom more than 90% of colon cancers test MSI positive (1, 2).