histiocytosis /his·tio·cy·to·sis/ (-si-to´sis) a condition marked by an abnormal appearance of histiocytes in the blood.
histiocytosis [his″te-o-si-to´sis]
acute disseminated Langerhans cell histiocytosis Letterer-Siwe disease.
Langerhans cell histiocytosis a generic term for a group of disorders characterized by proliferation of Langerhans cells (q.v.), believed to arise from disturbances in regulation of the immune system. Lesions may be unifocal or multifocal and may involve the bone marrow, endocrine system, or lungs.
sinus histiocytosis a disorder of the lymph nodes in which the distended sinuses are filled by histiocytes, as a result of active multiplication of the littoral cells.
histiocytosis X former name for Langerhans cell h.
his·ti·o·cy·to·sis (h s t - s -t ss)n. pl. his·ti·o·cy·to·ses (-s z) Abnormal multiplication of histiocytes. Also called histocytosis. |
histiocytosis [his″te-o-si-to´sis]
a condition marked by the abnormal appearance of histiocytes in the blood.
Langerhans cell histiocytosis a generic term that encompasses a group of disorders characterized by proliferation of Langerhans cells, which are specialized cells found in the epidermis that function as part of the immune system. These disorders are believed to arise from disturbances in regulation of the immune system. Children are more often affected than adults, and the bone marrow, endocrine system, and lungs may be involved (the lungs are affected more commonly in adults than in children). Langerhans cell histiocytosis is divided into unifocal and multifocal variants; there is also an acute, disseminated form (letterer-siwe disease). This group of disorders was formerly called histiocytosis X and was classified in three forms: Letterer-Siwe disease, Hand-Schüller-Christian disease, and eosinophilic granuloma. Called also eosinophilic granuloma, eosinophilic granulomatosis, and Langerhans cell granulomatosis.
Langerhans cell histiocytosis, acute disseminated Letterer-Siwe disease.
Langerhans cell histiocytosis, multifocal Langerhans cell histiocytosis occurring as erosive accumulations of proliferating Langerhans cells. It occurs most commonly in the marrow cavities of bones, but may also affect the skin, gingiva, lungs, and stomach. When the triad of involvement of the bones of the skull, exophthalmos, and diabetes insipidus is present, it is referred to as Hand-Schüller-Christian disease.
Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis occurring as a single osteolytic lesion, usually in a long or flat bone; it may be asymptomatic or may produce bone pain, tenderness, and swelling and, sometimes, pathologic fracture.
histiocytosis X former name for Langerhans cell histiocytosis.
histiocytosis
a condition marked by the abnormal appearance of histiocytes in the blood.
cutaneous histiocytosis
a benign proliferative disease in dogs, particularly Collies and Shetland sheepdogs. there are multiple plaques or nodules in the skin or subcutaneous tissue. The cause is unknown.
lipid histiocytosis
Niemann-Pick disease.
malignant histiocytosis
a systemic, progressive invasive proliferation of neoplastic histiocytes. Recognized as a familial disorder in Bernese mountain dogs with clinical signs of respiratory disease, involvement of the central nervous system, and anemia.
systemic histiocytosis
a proliferative disorder of histiocytes with infiltrates in the skin and lymph nodes. Occurs in young Bernese mountain dogs.
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