LCK

(redirected from Lymphocyte-specific protein tyrosine kinase)

LCK

A gene on chromosome 1p34.3 that encodes a member of the Src family of non-receptor tyrosine kinases that is involved in the selection and maturation of developing T cells. LCK localises to the plasma membrane and pericentrosomal vesicles and binds to cell surface receptors, including CD4 and CD8, and other signalling molecules.
 
Molecular pathology
LCK translocation t(1;7)(p34;q34) with TCRB may be found in leukaemia.
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References in periodicals archive ?
Among targets being addressed are Akt (protein kinase B, PKB); Angiopoietin-2; Aurora B (Aurora-1); Bcr-Abl; BRaf (B-Raf); c-Kit; Cyclin-dependent kinase 2 (CDK2); Cyclin-dependent kinase 7 (CDK7); Cyclin-dependent kinase 9 (CDK9); Delta-like 4 (DLL4); Epidermal growth factor (EGFr); focal adhesion kinase (FAK); HEr2/neu; Kinesin-like spindle protein (KSP)/Eg5; c-Kit; Lymphocyte-specific protein tyrosine kinase (Lck); Lyn; Hepatocyte growth factor receptor (HGFr)/c-Met; Notch 1 (TAN1); NF.

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