Rye Staging System

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Rye Staging System

A system for staging Hodgkin's disease delineated in 1966, which divided it into 4 distinct clinicopathological categories, based on data provided by the then popular method of lymphangiography. Cf Ann Arbor classification, Cotswolds classification.
Rye Classification–Hodgkin's disease
Lymphocytic predominant 10% of cases, more common in young adult ♂, usually early/low-stage disease without 'B' symptoms, 5-year survival: 90%
Nodular sclerosing 40%; more common in young adult ♀, usually early and low-stage disease with or without 'B' symptoms, 5-year survival: 70%
Mixed cellularity 40%; more common in young adult ♂, often stage II-III disease with or without 'B' symptoms, 5-year survival: 50%
Lymphocyte-depleted 10%; more common in older adult ?, usually stage III-IV disease with or without 'B' symptoms, 5-year survival, 30%
References in periodicals archive ?
Generally, there are four subtypes of CHL; nodular sclerosis, mixed cellularity, lymphocyte-rich, and lymphocyte-depleted.
An increase in the incidence of lymphocyte-predominant and lymphocyte-depleted subtypes has also been reported.
Because of her symptoms of fever and night sweats and the histologic findings demonstrating HD, lymphocyte-depleted type, the patient received cyclophosphamide, doxorubicin, vincristine (Oncovin), and prednisone chemotherapy for the next 6 months without any serious adverse effects.
Ber-H2 reacts with approximately 95% of cases of anaplastic large cell lymphoma (ALCL) and Reed-Sternberg cells and variants in about 90% of cases of nodular sclerosis, mixed cellularity, and lymphocyte-depleted Hodgkin lymphoma.

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