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betamethasone acetate and sodium phosphate
Pharmacologic class: Glucocorticoid (inhalation)
Therapeutic class: Antiasthmatic, antiinflammatory (steroidal)
Pregnancy risk category C
Stabilizes lysosomal neutrophils and prevents their degranulation, inhibits synthesis of lipoxygenase products and prostaglandins, activates anti-inflammatory genes, and inhibits various cytokines
Solution for injection: 3 mg betamethasone sodium phosphate with 3 mg betamethasone acetate/ml
Suspension for injection (acetate, phosphate): 6 mg (total)/ml
Syrup: 0.6 mg/5 ml
Tablets: 0.6 mg
Tablets (effervescent): 0.5 mg
Tablets (extended-release): 1 mg
Indications and dosages
➣ Inflammatory, allergic, hematologic, neoplastic, autoimmune, and respiratory diseases; prevention of organ rejection after transplantation surgery
Adults: 0.6 to 7.2 mg/day P.O. as single daily dose or in divided doses; or up to 9 mg I.M. of betamethasone acetate and sodium phosphate suspension.
➣ Bursitis or tenosynovitis
Adults: 1 ml of suspension intrabursally
➣ Rheumatoid arthritis or osteoarthritis
Adults: 0.5 to 2 ml of suspension intra-articularly
• Respiratory distress syndrome
• Hypersensitivity to drug
Use cautiously in:
• systemic infections, hypertension, osteoporosis, diabetes mellitus, glaucoma, renal disease, hypothyroidism, cirrhosis, diverticulitis, thromboembolic disorders, seizures, myasthenia gravis, heart failure, ocular herpes simplex, emotional instability
• patients receiving systemic corticosteroids
• pregnant patients
• children younger than age 6.
• Give as a single daily dose before 9:00 A.M.
• Give oral dose with food or milk.
• Administer I.M. injection deep into gluteal muscle (may cause tissue atrophy).
☞ Don't give betamethasone acetate I.V.
• Be aware that typical suspension dosage ranges from one-third to one-half of oral dosage given q 12 hours.
☞ To avoid adrenal insufficiency, taper dosage slowly and under close supervision when discontinuing.
• Know that drug may be given with other immunosuppressants.
CNS: headache, nervousness, depression, euphoria, psychoses, increased intracranial pressure
CV: hypertension, thrombophlebitis, thromboembolism
EENT: cataracts, burning and dryness of eyes, rebound nasal congestion, sneezing, epistaxis, nasal septum perforation, difficulty speaking, oropharyngeal or nasopharyngeal fungal infections
GI: nausea, vomiting, anorexia, dry mouth, esophageal candidiasis, peptic ulcers
Metabolic: decreased growth, hyperglycemia, cushingoid appearance, adrenal insufficiency or suppression
Musculoskeletal: muscle wasting, muscle pain, osteoporosis, aseptic joint necrosis
Respiratory: cough, wheezing, bronchospasm
Skin: facial edema, rash, contact dermatitis, acne, ecchymosis, hirsutism, petechiae, urticaria, angioedema
Other: loss of taste, bad taste, weight gain or loss, Churg-Strauss syndrome, increased susceptibility to infection, hypersensitivity reaction
Drug-drug. Amphotericin B, loop and thiazide diuretics, ticarcillin: additive hypokalemia
Barbiturates, phenytoin, rifampin: stimulation of betamethasone metabolism, causing decreased drug effects
Digoxin: increased risk of digoxin toxicity
Fluoroquinolones (such as ciprofloxacin, norfloxacin): increased risk of tendon rupture
Hormonal contraceptives: blockage of betamethasone metabolism
Insulin, oral hypoglycemics: increased betamethasone dosage requirement, diminished hypoglycemic effects
Live-virus vaccines: decreased antibody response to vaccine, increased risk of neurologic complications
Nonsteroidal anti-inflammatory drugs: increased risk of adverse GI effects
Drug-diagnostic tests. Calcium, potassium: decreased levels
Cholesterol, glucose: increased levels
Nitroblue tetrazolium test for bacterial
infection: false-negative result
Drug-herbs. Echinacea: increased immune-stimulating effects
Ginseng: increased immune-modulating effects
Drug-behaviors. Alcohol use: increased risk of gastric irritation and GI ulcers
• Monitor weight daily and report sudden increase, which suggests fluid retention.
• Monitor blood glucose level for hyperglycemia.
• Assess serum electrolyte levels for sodium and potassium imbalances.
• Watch for signs and symptoms of infection (which drug may mask).
• Advise patient to report signs and symptoms of infection.
• Tell patient to report visual disturbances (long-term drug use may cause cataracts).
• Instruct patient to eat low-sodium, high potassium diet.
☞ Advise patient to carry medical identification describing drug therapy.
• Inform female patients that drug may cause menstrual irregularities.
☞ Caution patient not to stop taking drug abruptly.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.
betamethasone/be·ta·meth·a·sone/ (ba″tah-meth´ah-sōn) a synthetic glucocorticoid, the most active of the antiinflammatory steroids; used topically as the benzoate, dipropionate, or valerate salts as an antiinflammatory, topically or rectally as the sodium phosphate salt as an antiinflammatory, and systemically as the base or the combination of sodium phosphate and acetate salts as an antiinflammatory, as a replacement for adrenal insufficiency, and as an immunosuppressant.
betamethasoneA corticosteroid drug used directly on the skin to treat ECZEMA and PSORIASIS, by inhalation to treat ASTHMA, by mouth for more severe allergic conditions and by injection to reduce brain swelling in head injuries, tumour and infections. The drug is on the WHO official list. Brand names are Betnelan, Betnesol, Betnovate, Bettamousse and Vista-Methasone.
betamethasonesemisynthetic glucocorticoid with anti-inflammatory and toxic effects, similar to cortisol; more potent than prednisolone
betamethasone (valerate, betamethasone benzoate, betamethasone dipropionate) (bā´təmeth´əsōn),
drug class: topical corticosteroid;
action: interacts with steroid cytoplasmic receptors to induce antiinflammatory effects; possesses antipruritic, antiinflammatory actions;
uses: treatment of psoriasis, eczema, contact dermatitis, pruritus, and oral ulcerative inflammatory lesions.