lupus nephritis (redirected from Lupus nephritis-)

nephritis /ne·phri·tis/ (nĕ-fri´tis) pl. nephri´tides   [Gr.] inflammation of the kidney; a focal or diffuse proliferative or destructive disease that may involve the glomerulus, tubule, or interstitial renal tissue.

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glomerular nephritis  glomerulonephritis.

interstitial nephritis  primary or secondary disease of the renal interstitial tissue.

lupus nephritis  glomerulonephritis associated with systemic lupus erythematosus.

potassium-losing nephritis  see under uropathy.

radiation nephritis  kidney damage caused by ionizing radiation; symptoms include glomerular and tubular damage, hypertension, and proteinuria, sometimes leading to renal failure. It may be acute or chronic, and some varieties do not manifest until years after the radiation exposure.

salt-losing nephritis  see under nephropathy.

transfusion nephritis  nephropathy following transfusion from an incompatible donor.

tubulointerstitial nephritis  nephritis of the renal tubules and interstitial tissues, usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease. An acute type and a chronic type have been distinguished.

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lupus nephritis

n.

Glomerulonephritis that occurs with systemic lupus erythematosus and is characterized by hematuria progressing to renal failure.

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nephritis

inflammation of the kidney; a focal or diffuse proliferative or destructive disease that may involve the glomerulus, tubule or interstitial renal tissue. See also glomerulonephritis, interstitial nephritis (below), nephrosis, pyelonephritis.

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autoimmune nephritis

see glomerulonephritis.

embolic nephritis

caused by infected emboli lodging in renal vessels. One or more abscesses may develop, causing signs referable to toxemia. There may be intermittent pyuria. Renal dysfunction is likely only if most of the renal mass is destroyed.

glomerular nephritis

see glomerulonephritis.

interstitial nephritis

a diffuse lesion characterized by interstitial inflammation and fibrosis, sometimes attributed to hematogenous infection with Leptospira spp. There is a secondary glomerular and vascular injury. It is manifested by polyuria, urine of low specific gravity, and terminal uremia.

lupus nephritis

glomerulonephritis associated with systemic lupus erythematosus.

parenchymatous nephritis

nephritis affecting the parenchyma of the kidney.

suppurative nephritis

a form accompanied by suppuration and abscessation of the kidney.

transfusion nephritis

nephropathy following transfusion from an incompatible donor.

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lupus nephritis

Lupus glomerular disease, lupus nephropathy Rheumatology Any nephropathy seen in systemic lupus erythematosus  Pathogenesis Classes II-V are attributed to deposition of DNA-anti-DNA immune complexes containing Igs, complement,  cryoglobulins Management Prednisone, cyclophosphamide

Lupus nephritis–WHO classification

Class I Normal–rarely recognized

Class II Mesangial lupus GN–10% of Pts Minimal clinical disease, mild hematuria, mild proteinuria LM Granular mesangial deposition of Ig and complement

Class III Focal proliferative glomerulonephritis–±¹⁄₃ of Pts Moderate clinical manifestations, recurrent hematuria, moderate proteinuria, possible progression to renal failure LM Focal swelling and proliferation of endothelial and mesangial cells, neutrophil infiltration, fibrinoid debris

Class IV Diffuse proliferative GN–45-50% Overtly symptomatic, microscopic or gross hematuria, proteinuria ± nephrotic syndrome, ± hypertension, often ↓ GFR LM Global glomerular involvement, proliferation of endothelial and mesangial, and sometimes epithelial cells

Class V Membranous GN–10% Overtly symptomatic, microscopic or gross hematuria, severe proteinuria with nephrotic syndrome, HTN, ↓ GFR LM Thickening of capillary walls similar to idiopathic membranous GN

GFR Glomerular filtration rate GN Glomerulonephritis  LM Light microscopy WHO classification  

Note: Plasmapheresis does not improve the clinical outcome in LN NEJM 1992; 326:1373oa