Lupus erythematosus (redirected from Lupus disease)

lupus er·y·the·ma·to·sus (r-thm-tss, -thm-)

n.

1. Abbr. LE A chronic disease of unknown origin characterized by red, scaly lesions or patches on the face and upper portion of the trunk.

2. Systemic lupus erythematosus.

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Lupus erythematosus

A chronic inflammatory disease in which inappropriate immune system reactions cause abnormalities in the blood vessels and connective tissue.

Mentioned in: Abortion, Therapeutic, Alopecia, Diuretics, Dysfunctional Uterine Bleeding

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lupus erythematosus Disseminated lupus erythematosus, lupus, systemic lupus erythematosus Rheumatology An idiopathic multisystem collagen vascular (connective tissue) disorder Epidemiology Affects ±40/105–North America, Europe, blacks/Hispanics > whites, ♀:♂ ratio = 3:1; 80% onset during childbearing yrs Clinical Vasculitis, serositis, synovitis, cerebral, renal, skin involvement Cause of death Sepsis 40%, CVS 20%, CNS 10%, 10% nephritis with possible renal failure, others 20%. See ANA-negative systemic lupus erythematosus, Anticardiolipin antibody, Antinuclear antibody, Butterfly rash.

Systemic lupus erythematosus–1982 revised criteria

1. Malar rash Fixed erythema, in particular over the malar eminences

2. Discoid rash Raised erythematous patches with adherent hyperkeratotic scaling; atrophic scarring in some old lesions

3. Photosensitivity Unusual skin rashes in response to sunlight

4. Oral ulcers Oral or nasopharyngeal ulcers

5. Arthritis Nonerosive arthritis of 2+ joints, accompanied by tenderness, swelling, or effusions

6. Serositis  

 a. Pleuritis OR

 b. Pericarditis

7. Renal disease  

 a. Persistent proteinuria > 0.5 g/day OR

 b. Cellular casts

8. Neurologic disorder  

 a. Seizures without substance use or medical disease OR

 b. Psychosis in absence of substance use or medical disease

9. Hematologic disorder  

 a. Hemolytic anemia OR

 b. Leukopenia OR

 c. Lymphocytopenia

 d. Thrombocytopenia

10. Immunologic disorder  

 a. Positive LE cell prep–this test was abandoned in the mid-1990s

 b. Anti-DNA antibody

 c. Anti-Sm antibody

 d. False positive serological test for syphilis

11 Antinuclear antibody Abnormal titers of ANA in absence of drugs known to be associated with drug-induced lupus erythematosus