lupus anticoagulant


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lu·pus an·ti·co·ag·u·lant (LA),

antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.

lupus anticoagulant

an antibody specific for phospho-lipoproteins or phospholipid components of coagulation factors, found in patients with systemic lupus erythematosus. It causes an increase in partial thromboplastin time and is associated with arterial and venous thrombosis, fetal loss, and thrombocytopenia.

lupus anticoagulant

Lupus inhibitor Lab Medicine Any IgG or IgM class antibody that arise spontaneously in Pts with SLE; while LAs produce in vitro interference with phospholipid-dependent coagulation–eg, activated partial thromboplastin time–aPTT and kaolin clotting time assays in specimens from Pts with LE, they do not produce in vivo coagulopathy without other platelet or coagulation defects or drug-induced antibodies; LAs also occur in Pts with HIV, DVT, and other conditions Lab ↑ aPTT; LAs interfere with derivative assays for factors VIII, IX, XI, and XII. See Systemic lupus erythematosus. Cf Anticardiolipin antibodies.

lu·pus an·ti·co·ag·u·lant

(lū'pŭs an'tē-kō-ag'yŭ-lănt)
Antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.

lupus anticoagulant

An antibody, or groups of antibodies, to negatively-charged phospholipids liable to be associated, paradoxically, with a tendency for blood to clot within the blood vessels. This may lead to deep vein thrombosis, arterial thrombosis with strokes and heart attacks and, in pregnant women, a strong tendency to fetal death and abortion. Some patients with LUPUS ERYTHEMATOSUS are known to have a positive result in tests for syphilis while not suffering from the disease. This effect is caused by the lupus anticoagulant. See also HUGHES' SYNDROME.
References in periodicals archive ?
falciparum associated with SLE, but none of these studies mention if the test subjects had concurrent circulating lupus anticoagulant (17-20).
ISTH/SSC lupus anticoagulant testing guidelines: how far have these been adopted by laboratories?
Those considered to be pathogenic, according to the last consensus conference held in Sydney (3), are the lupus anticoagulant, anti-[beta]2 GPI, and anticardiolipins.
Thromboelastography assessment of coagulation status in parturients with lupus anticoagulant receiving heparin therapy.
Prevalence of prolonged aPTT and lupus anticoagulant in autoimmune thyroid disease.
We then performed PT; activated partial thromboplastin time (APTT); fibrinogen (clottable and immunological); d-dimer; reptilase time; thrombin times; coagulation factors II, V, VII, VIII, IX, X, XI, XII; anti-thrombin (AT); alpha-2 antiplasmin (AP); protein C (PC); mixing studies (using rabbit normal plasma); lupus anticoagulant screening and confirmatory testing (dilute Russell's viper venom [American Diagnostica, Greenwich CT], STACLOT LA, [Diagnostica-Stago, Inc.
The presence of antiphospholipid antibodies, lupus anticoagulant and anticardiolipin, correlates with changes in the patient's CT/MRI.
Features of APS include hemolytic anemia, thrombocytopenia, venous and arterial occlusions, livedo reticularis, pulmonary manifestations, recurrent fetal loss, neurologic manifestations (stroke, transverse myelitis, Guillain-Barre syndrome); and a positive Coombs test, anticardiolipin antibodies, or lupus anticoagulant activity (1).
Biopool's Lupus Anticoagulant (LA) Positive Control Plasma is the first product of its kind that can be used with all of the commonly employed screening and confirmatory tests for LA, used in identifying individuals at risk for thrombotic disease.
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder defined by the occurrence of recurrent vascular (venous and arterial) thrombosis and pregnancy morbidity in the presence of persistently elevated antiphospholipid antibodies (aPL), anticardiolipin IgG/ IgM, lupus anticoagulant and anti-[beta]2-glycoprotein-1 IgG/IgM.
Lupus anticoagulant was ruled out by the results of 2 different assays (lupus-sensitive aPTT and diluted Russell viper venom time), as suggested by current guidelines (6).
APS was diagnosed in patients with arterial and/or venous thrombosis based on the presence of lupus anticoagulant (LA) or anticardiolipin antibodies (ACA) (1).