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lupus anticoagulant

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia, Hutchinson 0.09 sec.
lupus anticoagulant Lupus inhibitor Lab Medicine Any IgG or IgM class antibody that arise spontaneously in Pts with SLE; while LAs produce in vitro interference with phospholipid-dependent coagulation–eg, activated partial thromboplastin time–aPTT and kaolin clotting time assays in specimens from Pts with LE, they do not produce in vivo coagulopathy without other platelet or coagulation defects or drug-induced antibodies; LAs also occur in Pts with HIV, DVT, and other conditions Lab ↑ aPTT; LAs interfere with derivative assays for factors VIII, IX, XI, and XII. See Systemic lupus erythematosus. Cf Anticardiolipin antibodies.


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Lupus anticoagulant is a term used to describe a phenomenon in aPTT testing that occurs when a patient's polyclonal antibodies influence the phospholipid-dependent reaction.
Unidentified coagulation disorders in post-tonsillectomy hemorrhage by Remmert, Stephan / Ear, Nose and Throat Journal
Researchers have now identified two closely related lupus autoantibodies, anticardiolipin antibody and lupus anticoagulant (together called the antiphospholipid antibodies), that are associated with risk of miscarriage.
Systemic Lupus Erythematosus by Pamphlet by: Nat'l Inst. of Arthritis and Musculoskeletal & Skin Diseases
Features of APS include hemolytic anemia, thrombocytopenia, venous and arterial occlusions, livedo reticularis, pulmonary manifestations, recurrent fetal loss, neurologic manifestations (stroke, transverse myelitis, Guillain-Barre syndrome); and a positive Coombs test, anticardiolipin antibodies, or lupus anticoagulant activity (1).
Mycoplasma penetrans Bacteremia and Primary Antiphospholipid ... by Cassell, Gail H. / Emerging Infectious Diseases
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