Lupus

lupus /lu·pus/ (loo´pus) any of a group of skin diseases in which the lesions are characteristically eroded.

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chilblain lupus erythematosus  a form due to cold-induced microvascular injury, aggravated by cold; the lesions initially resemble chilblains but eventually assume the form of discoid lupus erythematosus.

cutaneous lupus erythematosus  one of the two main forms of lupus erythematosus, in which the skin may be either the only or the first organ or system involved. It may be chronic (discoid l. erythematosus), subacute (systemic l. erythematosus), or acute (characterized by an acute, edematous, erythematous eruption).

discoid lupus erythematosus  (DLE) a chronic form of cutaneous lupus erythematosus marked by red macules covered with scanty adherent scales that fall off and leave scars; lesions typically form a butterfly pattern over the bridge of the nose and cheeks, but other areas may be involved.

drug-induced lupus  a syndrome closely resembling systemic lupus erythematosus, precipitated by prolonged use of certain drugs, most commonly hydralazine, isoniazid, various anticonvulsants, and procainamide.

lupus erythemato´sus  (LE) a group of chronic connective tissue diseases manifested in two main types: cutaneous l. erythematosus and systemic l. erythematosus.

lupus erythemato´sus profun´dus  a form of cutaneous lupus erythematosus in which deep brawny indurations or subcutaneous nodules occur under normal or, less often, involved skin; the overlying skin may be erythematous, atrophic, and ulcerated and on healing may leave a depressed scar.

lupus erythemato´sus tu´midus  a variant of discoid or systemic lupus erythematosus in which the lesions are raised reddish purple or brown plaques.

hypertrophic lupus erythematosus  a form of discoid lupus erythematosus characterized by verrucous hyperkeratotic lesions.

lupus hypertro´phicus 

1. a variant of lupus vulgaris in which the lesions consist of a warty vegetative growth, often crusted or slightly exudative, usually occurring on moist areas near body orifices.

2. hypertrophic l. erythematosus.

lupus milia´ris dissemina´tus fa´ciei  a form marked by multiple, discrete, superficial nodules on the face, particularly on the eyelids, upper lip, chin, and nares.

neonatal lupus  a rash resembling discoid lupus erythematosus, sometimes with systemic abnormalities such as heart block or hepatosplenomegaly, in infants of mothers with systemic lupus erythematosus; it is usually benign and self-limited.

lupus per´nio 

1. a cutaneous manifestation of sarcoidosis consisting of violaceous smooth shiny plaques on the ears, forehead, nose, and digits, frequently associated with bone cysts.

2. chilblain l. erythematosus.

systemic lupus erythematosus  (SLE) a chronic generalized connective tissue disorder, ranging from mild to fulminating, marked by skin eruptions, arthralgia, arthritis, leukopenia, anemia, visceral lesions, neurologic manifestations, lymphadenopathy, fever, and other constitutional symptoms. Typically, there are many abnormal immunologic phenomena, including hypergammaglobulinemia and hypocomplementemia, deposition of antigen-antibody complexes, and the presence of antinuclear antibodies and LE cells.

lupus vulga´ris  the most common and severe form of tuberculosis of the skin, most often affecting the face, with formation of red-brown patches of nodules in the dermis that progressively spread peripherally with central atrophy, causing ulceration and scarring and destruction of cartilage in involved sites.

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lu·pus (lps)

n.

1. Systemic lupus erythematosus.

2. Any of various chronic skin conditions characterized by ulcerative lesions that spread over the body. No longer in scientific use.

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Lupus (systemic lupus erythematosus or SLE)

A chronic inflammatory autoimmune disorder that may affect many organ systems including the skin, joints, and internal organs.

Mentioned in: Knee Injuries, Menstrual Disorders

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lupus (lōōˑ·ps),

n an inflammatory, autoimmune disorder of connective tissue; occurs mainly in young women. Citation,

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lupus (loo´pus),

n a disease of the skin and mucous membrane.

Lupus.

lupus erythematosus (systemic lupus erythematosus, disseminated lupus erythematosus),

n a chronic inflammatory disease of unknown etiology affecting skin, joints, kidneys, nervous system, serous membranes, and often other organs of the body. The classical facial “butterfly rash” facilitates diagnosis, although the rash need not be present. Other skin areas, particularly those exposed to the sun, may be involved by a scaly lesion that is referred to as
discoid lupus erythematosus.

lupus erythematosus, discoid,

n a form in which only cutaneous lesions are present. These commonly appear on the face as atrophic plaques with erythema, hyperheratosis, follicular plugging, and telangiectasia.

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lupus

[L.] wolf, pike.

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lupus band

the deposit of immunoglobulin or complement, or both, at the basement membrane zone that can be demonstrated by direct immunofluorescence testing in lupus erythematosus.

lupus panniculitis, lupus profundus

circumscribed, subcutaneous nodules of panniculitis associated with lupus erythematosus.