CORIN

(redirected from Lrp4)
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CORIN

A gene on chromosome 4p13-p12 that encodes a serine-type endopeptidase which converts non-functional propeptide NPPA into active atrial natriuretic peptide hormone, resulting in natriuresis, diuresis and vasodilation. CORIN may also process pro-NPPB, the B-type natriuretic peptide.

Molecular pathology
Defects in CORIN cause pre-eclampsia/eclampsia type 5.
References in periodicals archive ?
Researchers have previously noticed autoantibodies against LRP4 in roughly 3 percent of myasthenia gravis patients.
They suggest that LRP4 antibodies are helpful biomarkers and potential therapeutic targets for ALS treatments.
The research team's leader explained that the LRP4 autoantibodies might be pathogenic in a subgroup of ALS patients.
In this pilot study the association of SF with 25 sequence variants within the following 9 genes: NRC31, ANKH, VDR, ROR2, CALCR, IL6, COL1A2, CBG, and LRP4 were assessed.
The new study shows that in the space between the neuron and its muscle cell, agrin and LRP4 first form two diverse work teams: each team has one agrin and one LRP4.
Most recently, GHSU researchers also helped identify LRP4 as an antibody target.
The scientists already are looking at the impact of the antibodies on the LRP4 complex.