antiinflammatory drug

(redirected from Loteprednol Etabonate)
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antiinflammatory drug 

A drug which inhibits or suppresses most inflammatory responses of an allergic, bacterial, traumatic or anaphylactic origin, as well as being immunosuppressant. They include the corticosteroids (e.g. betamethasone, dexamethasone, fluorometholone, hydrocortisone acetate, loteprednol etabonate, prednisolone, rimexolone, triamcinolone). They are sometimes combined with an antibiotic drug (e.g. betamethasone combined with neomycin or sulfacetamide, dexamethasone combined with neomycin or polymyxin B). Corticosteroids have side effects, such as enhancing the activity of herpes simplex virus, fungal overgrowth, raising intraocular pressure or cataract formation.There are other antiinflammatory drugs that are non-steroidal (NSAID) and have little toxicity. They act mainly by blocking prostaglandin synthesis. These include diclofenac sodium, flurbiprofen sodium, indomethacin, ketorolac, nepafenac and oxyphenbutazone. See immunosuppressants; steroid.
References in periodicals archive ?
Efforts are also underway by Pharmos and Bausch & Lomb to complete the development of a third ophthalmic product which combines the anti-inflammatory properties of loteprednol etabonate with the antibiotic tobramycin.
NYSE: VRX and TSX: VRX), today announced that its next generation sub-micron gel formulation of loteprednol etabonate was statistically superior to placebo (vehicle gel) in eliminating inflammation and pain following cataract surgery by study day eight, the primary endpoints in the first Phase 3, multi-center, double-masked, vehicle-controlled, parallel-group study.
In the four-arm study, 514 patients undergoing cataract surgery at 47 clinical sites across the United States were randomized to receive either sub-micron loteprednol etabonate ophthalmic gel (0.
Prednisolone acetate 1% was discontinued and loteprednol etabonate 0.
The steroid loteprednol etabonate has also demonstrated efficacy in treating the signs and symptoms of CLGPC in several randomised controlled trials.
3% ophthalmic suspension), combining the proven anti-inflammatory power of loteprednol etabonate with the broad-spectrum anti-infective agent tobramycin; and Alrex([R] )(loteprednol etabonate ophthalmic suspension 0.
Pharmaceuticals sales growth reflected continued gains in prescriptions for the Company's proprietary eye drops containing loteprednol etabonate and higher sales of ocular vitamins.
Zylet is part of the loteprednol etabonate business that Pharmos sold to Bausch & Lomb in 2001.
It is gratifying that our collaborative development of our loteprednol etabonate business with Bausch & Lomb that produced two earlier successful proprietary anti-inflammatory products, Lotemax and Alrex, has culminated in the commercialization of Zylet.
The corticosteroid component of Zylet is loteprednol etabonate, Bausch & Lomb's proven, patented, site-specific steroid, which, for the first time, is combined with the time-tested efficacy of tobramycin to be the first novel ophthalmic corticosteroid/antibiotic combination approved by FDA in more than 15 years.
Zylet is the third product containing loteprednol etabonate approved by the FDA.