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omeprazole |
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omeprazole /omep·ra·zole/ (o-mep´ra-zōl) an inhibitor of gastric acid secretion used in the treatment of dyspepsia , gastroesophageal reflux disease, disorders of gastric hypersecretion, and peptic ulcer, including that associated with Helicobacter pylori infection.
omeprazole (ōmep´r n brand name: Prilosec; drug class: antisecretory compound; action: suppresses gastric secretion by inhibiting hydrogen/potassium ATPase enzyme system in the gastric parietal cell; uses: gastroesophageal reflux disease (GERD), severe erosive esophagitis, pathologic hypersecretory conditions (Zollinger-Ellison syndrome, mastocytosis, multiple endocrine adenomas). omeprazole a substituted benzimidazole that is a long-acting inhibitor of gastric ATPase; used in the treatment of gastric ulcers. omeprazole Losec (CA) (UK), Heartburn Relief (UK), Prilosec, Prilosec OTC, Zegerid, Zanprol (UK) Pharmacologic class: Proton pump inhibitor Therapeutic class: Antiulcer drug Pregnancy risk category C ActionReduces gastric acid secretion and increases gastric mucus and bicarbonate production, creating protective coating on gastric mucosa and easing discomfort from excess gastric acid AvailabilityCapsules (delayed-release): 10 mg, 20 mg, 40 mg Powder for oral suspension: 20 mg Tablets (delayed-release): 20 mg ⊘Indications and dosages ➣ Gastroesophageal reflux disease Adults: 20 mg P.O. (capsules, powder) daily for 4 weeks ➣ Erosive esophagitis Adults: 20 mg P.O. (capsules, powder) daily for 4 to 8 weeks ➣ Short-term treatment of active duodenal ulcer Adults: 20 mg P.O. (capsules, powder) daily for 4 weeks. Some patients may need 4 additional weeks of therapy. ➣ To reduce risk of duodenal ulcers caused by Helicobacter pylori Adults: 40 mg P.O. (capsules) daily in morning, given with clarithromycin t.i.d. for 2 weeks; then 20 mg daily for 2 weeks ➣ Gastric ulcers Adults: 40 mg P.O. (capsules) daily for 4 to 8 weeks ➣ Pathologic hypersecretory conditions, including Zollinger-Ellison syndrome Adults: Initially, 60 mg P.O. (capsules) daily; may increase up to 120 mg t.i.d. Divide daily dosages above 80 mg. ➣ Frequent heartburn (two or more episodes a week) Adults ages 18 and older: 20 mg P.O. (OTC tablets) daily for 14 days Off-label uses• Posterior laryngitis Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Give 30 to 60 minutes before a meal, preferably in morning.
Adverse reactionsCNS: dizziness, headache, asthenia GI: nausea, vomiting, diarrhea, constipation, abdominal pain Musculoskeletal: back pain Respiratory: cough, upper respiratory tract infection Skin: rash InteractionsDrug-drug. Ampicillin, cyanocobalamin, iron salts, ketoconazole: reduced absorption of these drugs Clarithromycin: increased omeprazole blood level Diazepam, phenytoin, warfarin: prolonged elimination and increased effects of these drugs Digoxin: increased digoxin absorption and blood level, possible digoxin toxicity Drugs metabolized by CYP450 system: competitive metabolism Drug-diagnostic tests. Alanine phosphatase, alkaline aminotransferase, aspartate aminotransferase, bilirubin: increased levels Gastrin: increased level during first 1 to 2 weeks of therapy Patient monitoring• Assess vital signs. Patient teaching• Tell patient to take 30 to 60 minutes before a meal, preferably in morning. omeprazole Prilosec® Therapeutics A proton pump inhibitor used to manage GERD; heartburn; erosive esophagitis; maintenance of healed erosive esophagitis; short-term management of active duodenal ulcer and active benign gastric
ulcer, and for certain hypersecretory conditions; combined with clarithromycin to eradicate H pylori associated with duodenal ulcers. See GERD, Helicobacter pylori. Cf H2 blockers. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Losec issue continues to hang heavily over AstraZeneca's short-term future. AstraZeneca also ordered an IT-based sales support training system for Nexium, which is the successor to Losec. As a result of this advanced work, Losec is protected by a number of different patents," said Dr. |
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