losartan


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losartan

 [lo-sahr´tan]
an angiotensin II receptor antagonist used as an antihypertensive; used as the potassium salt.

losartan

/lo·sar·tan/ (lo-sahr´tan) an angiotensin II receptor antagonist, used as an antihypertensive; used as the potassium salt.

losartan

(lō-sär′tăn)
n.
An angiotensin II receptor blocker drug, C22H23ClN6O, used in the form of its potassium salt to treat hypertension.

losartan

an antihypertensive.
indications It is used to treat hypertension, either alone or in combination with other drugs.
contraindications Factors that prohibit the use of this drug are known hypersensitivity to tramadol and second- and third-trimester pregnancy.
adverse effects Life-threatening effects are cerebrovascular accident and myocardial infarction. Other adverse effects are anxiety, confusion, abnormal dreams, migraine, tremor, vertigo, task perversion, angina pectoris, second-degree atrioventricular block, hypotension, blurred vision, burning eyes, conjunctivitis, anorexia, constipation, dry mouth, flatulence, gastritis, vomiting, impotence, nocturia, urinary frequency, urinary tract infection, anemia, alopecia, dermatitis, dry skin, flushing, photosensitivity, rash, pruritus, sweating, gout, cramps, myalgia, pain, stiffness, congestion, dyspnea, and bronchitis. Common side effects are dizziness, insomnia, arrhythmias, diarrhea, dyspepsia, cough, and upper respiratory infection.

losartan

Cozaar® Pharmacology A sartan which blocks angiotensin II–A-II from binding to AT1, ↓ proteinuria and filtration fraction, inhibits secretion of aldosterone by the adrenal cortex, and ↑ uric acid excretion; in Pts with CHF, losartan ↓ afterload, ↑ cardiac output–effects shared by ACE inhibitors—and prevent left ventricular hypertrophy Side effects Vertigo. See Angiotensin II receptor antagonist, ELITE.

losartan

An angiotensin II antagonist drug used to treat high blood pressure (HYPERTENSION). In the LIFE trial of this drug, reported on in 2003, a subgroup of diabetic patients taking the drug showed a 37 percent reduction in mortality from heart attacks or strokes and a 39 percent reduction in overall mortality over people on other treatment. The drug appears to be effective in preventing sudden death from heart arrhythmias. A brand name is Cozaar. The drug is available combined with the diuretic drug HYDROCHLOROTHIAZIDE under the brand name Cozaar-Comp.
References in periodicals archive ?
Consequently, the current study was designed to examine effects of losartan and candesartan in a pre-established model of fibrosis in rats.
AD is the most common form of dementia and it affects memory and brain function, but researchers believe losartan can slow down progression by improving blood flow in the brain and altering the chemical pathways that cause brain cell damage, brain shrinkage and memory problems in AD.
It was concluded that losartan was toxic to developing fetus.
As previously reported, the main finding in LIFE was that losartan conferred benefits beyond blood pressure control (Lancet.
The decision "must be individualized, taking into consideration the efficacy and cost of the alternative antihypertensive drug, as well as the potential but as yet unproven cardiovascular and renal benefits of lowering the serum urate with a more potent hypouricemic to a degree not likely to be attained with losartan alone," he said.
Losartan efficiently reduces proteinuria with adequate tolerance in presence of adequate glycaemic control.
Objective of this study was to evaluate the bene-ficial role of losartan in comparison with pioglitazone on insulin resistance in a type 2 diabetic rat model fed on high fat and sucrose diet.
To test this hypothesis, losartan as a selective antagonist of angiotensin-II (Ang-II) type-1 ([AT.
Amlodipine besylate (AMLO) is a long-acting dihydropyridine calcium antagonist whereas losartan potassium (LST) is an angiotensin II type 1 receptor antagonist; both these agents are currently being used in hypertension.