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loricrin

   Also found in: Acronyms 0.01 sec.
loricrin
Dermatology An insoluble glycine/serine-rich transglutaminase substrate protein cross-linked to the cornified cell envelope of the upper dermis


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Loricrin geninde ortaya cikan mutasyonlar sonucunda gelisen ve iktiyozun eslik ettigi Camisa tipi ve Connexin 26 genindeki mutasyonlarin neden oldugu, sagirlik ile seyreden VS olmak uzere (klasik tip) iki tipi tanimlanmistir.
Bu hucrelerdeki involucrin, profilaggrin ve loricrin ekspresyonunda azalma ve keratohiyalin granullerinde kayip gozlenmistir.
Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14.
 
 
 
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