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Related to Lomotil: Diphenoxylate


trademark for combination preparations of diphenoxylate hydrochloride and atropine sulfate, used in treatment of diarrhea.

diphenoxylate hydrochloride and atropine sulfate (co-phenotrope (UK))

Lomotil, Lonox

Pharmacologic class: Anticholinergic, meperidine congener

Therapeutic class: Antidiarrheal

Controlled substance schedule V

Pregnancy risk category C


Acts on smooth muscle of GI tract by decreasing peristalsis, which inhibits motility. (Small amount of atropine is added to reduce abuse potential.)


Liquid: 2.5 mg diphenoxylate and 0.025 mg atropine/5 ml

Tablets: 2.5 mg diphenoxylate and 0.025 mg atropine

Indications and dosages


Adults: Initially, 5 mg P.O. three to four times daily, then 5 mg/day as needed (not to exceed 20 mg/day). Decrease dosage when desired response occurs.

Children: Initially, 0.3 to 0.4 mg/kg P.O. (liquid only) daily in four divided doses. Decrease dosage when desired response occurs.

Dosage adjustment

• Elderly patients


• Hypersensitivity to drug

• Obstructive jaundice

• Diarrhea associated with pseudomembranous colitis or enterotoxinproducing bacteria

• Angle-closure glaucoma

• Concurrent MAO inhibitor use

• Children younger than age 2


Use cautiously in:

• inflammatory bowel disease; prostatic hypertrophy; severe hepatic disease (use with extreme caution)

• concurrent use of drugs that cause physical dependence; history of physical drug dependence

• elderly patients

• pregnant or breastfeeding patients

• children (safety not established in children younger than age 12).


Don't confuse brand name Lomotil with Lamictal (an anticonvulsant). Serious errors have been reported.

• Withhold drug if patient has severe fluid or electrolyte imbalance.

• Administer with food if GI upset occurs.

Don't give within 14 days of MAO inhibitors.

Adverse reactions

CNS: dizziness, confusion, drowsiness, headache, insomnia, nervousness

CV: tachycardia

EENT: blurred vision, dry eyes

GI: nausea, vomiting, constipation, epigastric distress, ileus, dry mouth

GU: urinary retention

Skin: flushing


Drug-drug. CNS depressants (including antihistamines, sedative-hypnotics, opioids): increased CNS depression

Anticholinergic-like drugs (including tricyclic antidepressants, disopyramide): increased anticholinergic effects

MAO inhibitors: hypertensive crisis

Drug-diagnostic tests. Amylase: increased level

Drug-herbs. Angel's trumpet, jimsonweed, scopolia: increased anticholinergic effects

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

Assess for and report abdominal distention and signs or symptoms of decreased peristalsis.

• Watch for signs and symptoms of dehydration.

• Assess frequency and consistency of bowel movements.

Patient teaching

• Instruct patient to report persistent diarrhea.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Tell patient that prolonged use may lead to dependence.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.


A trademark for a drug combination of diphenoxylate hydrochloride and a sulfate salt of atropine.


a trademark for an antidiarrheal fixed-combination drug containing an antiperistaltic (diphenoxylate hydrochloride) and an anticholinergic (atropine sulfate).


A brand name for a mixture of DIPHENOXYLATE and ATROPINE.
References in periodicals archive ?
In addition, a tablet, especially, AnGesid being used by heart patients, Lomotil for diarrhoea given instantly to cure the thyroid gland infection in throat, Migril tablet, Zentel syrup, Neomercazol tablet, Dormicum tablet, Ethaphilin syrup, Polyfex skin ointment, and several medicines of anti-allergy have been taken away from the markets.
South Grafton, charged with trafficking in marijuana, dismissed; possession of marijuana, found guilty, placed on probation for 2 years, fined $150, ordered to remain drug free and submit to random screening; drug violation near a school, dismissed; conspiracy to violate drug law, dismissed; possession of OxyContin, found guilty, placed on probation for 2 years concurrent with previous sentence; possession of Percocet, possession of Endocet, possession of Vicodin, possession of diazepam, possession of Tolectin, possession of Lomotil, possession of marijuana with intent to distribute, continued without finding for 1 year with supervised probation, fined $50, ordered to remain drug free and submit to random screening.
The majority of these patients are told to decrease their exercise or are prescribed the requisite "drug-that-doesn't-really-match-the-complaint-but-l'll-prescribe-it-anyway," such as antidepressants for lethargy, ibuprofen for aches and pains, and Lomotil (diphenoxylate and atropine sulfate) for gastrointestinal disturbances.
Examples of these medications are Lomotil and Immodium.
The diarrhoea you describe can be alleviated using Imodium or Lomotil available over the counter.
Gastroenterologists were consulted; they recommended intravenous hyperalimentation, Lomotil, mist kaolin with morphine, and oral codeine at various times, without success.
s Lomotil as an adjunct therapy in the management of diarrhea.
Medications may be prescribed to decrease stool frequency, such as Imodium or Lomotil.
Trans-Scop, Antivert/Bonine, Marezine Antidiarrheals - Lomotil, Immodium, Donnagel, Parapectolin Antisecretory - Robinul, Donnatal, Levsin, Atropine, scopolamine,
Always carry Lomotil ( for digestive problems) and non-drowsy antihistamine tablets for allergies and rashes.
a Belgium-based Johnson & Johnson company that originally developed the prescription antidiarrheal drug Lomotil.