hepatotoxicity

(redirected from Liver toxicity)
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Related to Liver toxicity: toxic hepatitis, Toxic liver disease

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē),
The capacity of a drug, chemical, or other exposure to produce injury to the liver. Agents with recognized hepatotoxicity include carbon tetrachloride, alcohol, dantrolene sodium, valproic acid, and isonicotinic acid hydrazide.

hepatotoxicity

(hĕp′ə-tō-tŏk-sĭs′ĭ-tē, hĭ-păt′ō-)
n.
1. The quality or condition of being toxic or destructive to the liver.
2. The capacity of a substance to have damaging effects on the liver.

hep′a·to·tox′ic (-tŏk′sĭk) adj.

hepatotoxicity

[hep′ətōtoksis′itē]
Etymology: Gk, hēpar + toxikon, poison
the tendency of an agent, usually a drug or alcohol, to have a destructive effect on the liver.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)
The capacity of a drug, chemical, or other exposure to produce injury to the liver.

hepatotoxicity

The state of being poisonous (toxic) to the liver, or the degree to which a substance is toxic to the liver.

hepatotoxicity (hepˑ··tō·tkˈ·si·sit·ē),

n liver toxicity.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)
Capacity of a drug, chemical, or other exposure to injure the liver.
References in periodicals archive ?
On the other hand, he says, referring to the new findings of liver toxicity, "I'm glad we had only 50 or so patients in this trial, and not 50,000.
These data must demonstrate that there is a serum concentration of Proellex[R] below which there was no laboratory evidence of liver toxicity (i.
The use of our ACTIVTox testing system could help prevent recalls associated with liver toxicity," said James H.
Under the agreement, Cellumen will use its proprietary CellCiphr(R) toxicity risk assessment technology to profile blinded samples of known liver toxicity compounds including both failed and marketed drugs for the NCTR.
Because of that liver toxicity, pemoline was recommended only for second-line treatment of ADHD.
twice a day, there was a demonstration of more liver toxicity in the once a day arm vs.
Liver toxicity is very costly to the pharmaceutical industry, and is one of the two most common causes of drug failures.
SAN DIEGO, May 9 /PRNewswire/ -- Aviva Systems Biology has entered into a collaborative agreement with the Seattle-based, non-profit Institute for Systems Biology, to develop new antibodies for liver toxicity biomarker discovery.
The findings suggest that "patients who are getting a good therapeutic benefit from an endothelin antagonist, but are having problems with liver toxicity on bosentan, can be safely changed to sitaxsentan with a low likelihood of recurrence, and thereby still get the benefit of an endothelin antagonist," Raymond Benza, M.
The liver toxicity that is more common is an asymptomatic rise in liver enzymes that occurs in the first 6 weeks of treatment.
The two studies will address drug-related liver toxicity and a rare but serious drug-related skin condition called Stevens-Johnson Syndrome (SJS).
This information will be used by ADMET to identify cells that could be used in predictive toxicology assays that would enable pharmaceutical companies to identify subtle or idiosyncratic liver toxicity at an early stage in the development process.