Little's disease


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Little's disease

 [lit´'lz]
congenital spastic stiffness of the limbs, a form of cerebral spastic paralysis due to lack of development of the pyramidal tracts.

Little's disease

Little's disease

Bilateral congenital spastic diplegia A type of cerebral palsy with agenesis of the lower motor neurons in the legs, which affects ± 300,000, US; congenital cerebrovascular malformations and immune-related kernicterus account for some cases Clinical Spasticity, muscle weakness, mental retardation, and ocular defects, due to neonatal hypoxia, mechanical trauma and prematurity DiffDx Brain tumors, 'floppy infant' syndromes, leukodystrophy, muscular dystrophy. See Cerebral palsy, Floppy infant.

Little's disease

A common form of spastic paralysis (CEREBRAL PALSY) (William John Little, 1810–94, English surgeon).