Lisch nodule


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Lisch nod·ule

(lish),
iris hamartomas typically seen in type 1 neurofibromatosis.

Lisch nod·ule

(lish nod'yūl)
Iris hamartomas typically seen in association with type 1 neurofibromatosis.

Lisch nodule

(lish)
[Karl Lisch, Ger. scientist, 1907–1999]
A melanocytic hamartoma projecting from the surface of the iris of the eye. It is a well-defined, dome-shaped elevation that is clear to yellow or brown. These growths, which do not cause ophthalmological complications, may be seen without magnification, but examination with use of a slit lamp is needed to differentiate them from nevi of the iris. Lisch nodules are found only in patients with neurofibromatosis, type 1.

Lisch,

Karl, Austrian ophthalmologist, 1907-1999.
Lisch nodule - iris hamartomas typically seen in type 1 neurofibromatosis. Synonym(s): Sakurai-Lisch nodule
Sakurai-Lisch nodule - Synonym(s): Lisch nodule

Sakurai,

Japanese ophthalmologist.
Sakurai-Lisch nodule - Synonym(s): Lisch nodule
References in periodicals archive ?
Lisch nodules are innocuous iris hamartomas evident in patients older than 2 years (Fig.
The disease can manifest as one of several types of lesions, including cafe au lair spots, cutaneous tumors, plexiform lesions, axillary freckling, Lisch nodules of the iris, optic gliomas, and bony abnormalities.
According to the National Institutes of Health guidelines, NF1 is a clinical diagnosis necessitating two of the following criteria: 1) six or more cafe-au-lait macules >5 mm in diameter; 2) two or more neurofibromas; 3) freckling in the axillary or inguinal regions; 4) optic glioma; 5) two or more Lisch nodules (iris hamartomas); 6) sphenoid dysplasia or thinning of long bone cortex; and/or 7) a first-degree relative with NF1 (2-4).
During follow-up, the patient exhibited no other signs of head and neck neurofibromatosis, and an ophthalmologic examination detected no Lisch nodules in the iris.
Other investigations should include pure-tone audiometry to exclude bilateral neural hearing loss, an ophthalmologic examination to look for Lisch nodules (iris hamartoma), CT or MRI of the head and neck to search for other tumors (e.
Lisch nodules [Figure 3) can be easily seen by slit lamp examination, by focusing on the anterioT surface of the iris.
Lisch nodules are pigmented hamartomatous naevus, (11) which occur from proliferation of melanocytes and fibroblasts.