fat soluble

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fat soluble

Able to be dissolved in fats or fat solvents. Four of the vitamins, A, D, E and K, are fat soluble.
References in periodicals archive ?
Polyphenolic compounds are more efficient uncoupling as long as they have a higher number of hydroxyl groups per molecule transferring more protons, which increases their degree of lipophilicity (Mandalariet al.
The mechanism of antimalarial action of [Au(CQ)(PPh(3))] PF(6): Structural effects and increased drug lipophilicity enhance heme aggregation inhibition at lipid/water interfaces.
Fentanyl is available in many formulations, and its unique physicochemical properties, particularly its high lipophilicity, allow it to quickly enter the central nervous system and are responsible for its high potency (2) and high potential for abuse.
Additional key considerations are molecular weight and lipophilicity for potential skin penetration.
lipophilicity or water solubility) are measured to assess absorption potential and bioavailability as related to primary routes of exposure.
In small molecules, enhanced acidity and lipophilicity can result, making these fluorine-substituted compounds ideal as pharmaceuticals.
The prolonged activity of formoterol is also thought to be due to its lipophilicity, although formoterol is less lipophilic than salmeterol.
CA nisoldipine, nimodipine, nitrendipine, nifedipine, and nicardipine have AOA that correlates with their lipophilicity (modified Buege and Aust's method of TBA determination, applied in model of rat brain cortex ischemia/reperfusion) [87].
Besides, additional halides increased the lipophilicity of the membrane compounds and consequently also the sensor membrane lipophilicity.
Besides their precision, the emerging targeted drug delivery technologies are noted for their high lipophilicity, which enhances the entrapment efficiency of drugs.
Scleral permeability is dependent upon the molecular radius as opposed to the innate lipophilicity of the drug; macromolecules up to 70,000 Da can readily penetrate the sclera.