fat soluble

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fat soluble

Able to be dissolved in fats or fat solvents. Four of the vitamins, A, D, E and K, are fat soluble.
References in periodicals archive ?
A common feature of these compounds is lipophilicity, suggesting that this is a key factor for modulating antibiotic resistance in S.
When the octanol/water partition coefficient of each fluoroquinolone was determined by Tejedor et al, (21) marbofloxacin had the least lipophilicity and the smallest Vss value in contrast to the greatest lipophilicity and highest Vss value demonstrated by danofloxacin.
It was suggested that terpenoids and phenylpropanoids can penetrate the membrane of bacteria and reach the inner part of the cell because of their lipophilicity (Helander et al.
Our unique design elements are highlighted in this poster and include pharmacophore modification, prodrug utilization, thioamide isosteres, and strategic lipophilicity incorporation.
Thus, the alkyl chain length-counter ion combination for dodecyldimethylammoniumchloride-POSS (Q-12-Cl) provided the best balance of lipophilicity and diffusivity to enable both effective binding to the outer surface of the bacterium cell structure and diffusivity through the cell wall to the cell interior.
Teva targeted lansoprazole (Takeda's EP '726), which is nearly identical to rabeprazole, as the lead compound, arguing it would have been obvious to someone of ordinary skill in the art to choose lansoprazole, since it contains a fluorinated substituent that increases lipophilicity.
There are tricarbonylamide, phenolic diketone, and dimethylamine groups in tetracycline antibiotics, which can contribute to a marked pH-dependent speciation affecting aqueous solubility and lipophilicity.
In the largest cohort study to date, statin treatment was found to reduce the incidence of Alzheimer's disease, regardless of the drug's lipophilicity or the individual's apolipoprotein E genotype.
Thus they can have better lipophilicity characteristic and might penetrate cells more readily that extra-cellularly acting chelating agent like DMSA.
In small molecules, this attribute leads to enhanced acidity and lipophilicity and the ability to block metabolic pathways, making fluorine-substituted compounds ideal as pharmaceuticals.
The prolonged activity of formoterol is also thought to be due to its lipophilicity, although formoterol is less lipophilic than salmeterol.